Evidence map›Paper›PMID 39440956›Full record

ReviewClinical microbiology reviews2024

Comprehensive analysis of the global impact and distribution of tick paralysis, a deadly neurological yet fully reversible condition.

Yuan-Ping Deng, Yi-Tian Fu, Hany M Elsheikha, Mei-Ling Cao, Xing-Quan Zhu, Jin-Lei Wang, Xue-Ling Zhang, Shi-Chen Xie, Chaoqun Yao, Guo-Hua Liu

Abstract readReview
In one paragraph

Review in Clinical microbiology reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Tick-induced neurological disorders.Journal of neurology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuan-Ping Deng *Research Center for Parasites and Vectors, College of Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan, China.
Yi-Tian Fu *Research Center for Parasites and Vectors, College of Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan, China.
Hany M ElsheikhaFaculty of Medicine and Health Sciences, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Loughborough, United Kingdom.ORCID 0000-0003-3303-930X
Mei-Ling CaoResearch Center for Parasites and Vectors, College of Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan, China.
Xing-Quan ZhuCollege of Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi, China.ORCID 0000-0003-2530-4628
Jin-Lei WangState Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China.
Xue-Ling ZhangResearch Center for Parasites and Vectors, College of Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan, China.
Shi-Chen XieResearch Center for Parasites and Vectors, College of Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan, China.
Chaoqun YaoRoss University School of Veterinary Medicine and One Health Center for Zoonoses and Tropical Infectious Diseases, Ross University School of Veterinary Medicine, Basseterre, St. Kitts and Nevis.ORCID 0000-0003-2578-6604
Guo-Hua LiuResearch Center for Parasites and Vectors, College of Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan, China.ORCID 0000-0002-8434-899X

Funding

Hunan Provincial Natural Science Foundation of China 2023JJ5005MOST | National Natural Science Foundation of China (NSFC) 32172884 and 32473057
6 · The paper itself

Abstract

SUMMARYTick paralysis is a potentially fatal condition caused by neurotoxins secreted by the salivary glands of certain ticks. Documented cases have been reported worldwide, predominantly in the United States, Canada, and Australia, with additional reports from Europe and Africa. This condition also affects animals, leading to significant economic losses and adverse impacts on animal health and welfare. To date, 75 tick species, mostly hard ticks, have been identified as capable of causing this life-threatening condition. Due to symptom overlap with other conditions, accurate diagnosis of tick paralysis is crucial to avoid misdiagnosis, which could result in adverse patient outcomes. This review provides a comprehensive analysis of the current literature on tick paralysis, including the implicated tick species, global distribution, tick toxins, molecular pathogenesis, clinical manifestations, diagnosis, treatment, control, and prevention. Enhancing awareness among medical and veterinary professionals is critical for improving the management of tick paralysis and its health impacts on both humans and animals.

Indexed as

Global HealthNeurotoxinsTick BitesTick ParalysisAnimalsCost of IllnessHumansTicksNeurotoxinsclinical manifestationshuman casesneurotoxintick paralysistickstoxin

Identifiers

PMID39440956
PMCPMC11629633

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.