Evidence map›Paper›PMID 39440846›Full record

ArticleBiological research for nursing2025

Preterm Birth in African American Women: A Multi-Omic Pilot Study in Early Pregnancy.

Alexandra L Nowak, Nadia Saadat, Jiao Sun, Anna M Forsman, Xiaoyu Liang, Cara Joyce, Jennifer Woo, Christopher G Engeland, Dawn P Misra, Carmen Giurgescu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological research for nursing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alexandra L NowakMarcella Niehoff School of Nursing, Loyola University at Chicago, Maywood, IL, USA.ORCID 0000-0003-3457-593X
Nadia SaadatDepartment of Paediatrics, University of Michigan, Ann Arbor, MI, USA.
Jiao SunDepartment of Computer Science, University of Central Florida, Orlando, FL, USA.
Anna M ForsmanDepartment of Biology, Colby College, Waterville, ME, USA.
Xiaoyu LiangDepartment of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA.
Cara JoyceBiostatistics Core, Department of Medicine, Center for Translational Research and Education, Loyola University Chicago Stritch School of Medicine, Maywood, IL, USA.
Jennifer WooUniversity of Texas at Arlington, Arlington, TX, USA.
Christopher G EngelandBiobehavioral Health, College of Health and Human Development, Ross and Carol Ness College of Nursing, The Pennsylvania State University, University Park, PA, USA.
Dawn P MisraDepartment of Epidemiology and Biostatistics, MSU College of Human Medicine, East Lansing, MI, USA.
Carmen GiurgescuChatlos Foundation Endowed Chair in Nursing, University of Central Florida College of Nursing, Orlando, FL, USA.ORCID 0000-0002-4577-3184
Wei ZhangDepartment of Computer Science, University of Central Florida, Orlando, FL, USA.
Cindy M AndersonMaternal Infant Health, Martha S. Pitzer Center for Women, Children and Youth, The Ohio State University College of Nursing, Columbus, OH, USA.

Funding

Michigan Institute for Clinical and Health Research (MICHR)UM1TR004404 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Julie C Lumeng · 2023 to 2026
$39.8M
Reducing Health Disparities Through Informatics - Genomics SupplementT32NR007969 · NINR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SUZANNE BAKKEN, Rebecca Schnall · 2002 to 2026
$7.9M
CTSA K12 Program at the University of MichiganK12TR004374 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI VICKI L ELLINGROD, Leah Elizabeth Robinson · 2023 to 2026
$6.5M
Social Stressors and Inflammation: A Mixed Methods Approach to Preterm BirthR01MD011575 · NIMHD · UNIVERSITY OF CENTRAL FLORIDA · PI GIURGESCU, CARMEN · 2017 to 2021
$3.9M
Training in the Science of Health DevelopmentT32NR014225 · NINR · OHIO STATE UNIVERSITY · PI MARY E HAPP, Rita H Pickler · 2013 to 2026
$2.6M
Epigenetic aging, social factors, and preterm birth among Black womenR01MD018293 · NIMHD · UNIVERSITY OF CENTRAL FLORIDA · PI Carmen Giurgescu, Joyce Ellen Ohm · 2023 to 2026
$2.6M
Intelligent Sensor System for Early Illness Alerts in Senior HousingR01NR014255 · NINR · UNIVERSITY OF MISSOURI-COLUMBIA · PI RANTZ, MARILYN J · 2013 to 2015
$1.7M
Genomic signatures of inflammation: Pathways of racial discrimination, depressive symptoms, Vitamin D status with preterm birth among Black womenK23MD016431 · NIMHD · UNIVERSITY OF TEXAS ARLINGTON · PI WOO, JENNIFER · 2022 to 2024
$393k
Neighborhood Disorder and Epigenetic Regulation of Stress Pathways in Preterm BirthF31NR018363 · NINR · OHIO STATE UNIVERSITY · PI NOWAK, ALEXANDRA · 2019 to 2020
$79k
NCATS NIH HHS K12 TR004374NCATS NIH HHS UM1 TR004404NIMHD NIH HHS K23 MD016431NIMHD NIH HHS L60 MD001575NIMHD NIH HHS R01 MD011575NIMHD NIH HHS R01 MD018293NINR NIH HHS F31 NR018363NINR NIH HHS R01 NR014255NINR NIH HHS T32 NR007969NINR NIH HHS T32 NR014225
6 · The paper itself

Abstract

Preterm birth (PTB; <37 weeks completed gestation) is a devastating problem affecting over 13 million live births worldwide. In the U.S., African Americans experience significantly higher rates of PTB compared to non-Hispanic Whites. PTB disparities have been linked to social determinants of health (e.g., socioeconomic status, discrimination). However, the biological underpinnings related to these associations are unclear. DNA methylation (DNAm) is subject to environmental influences, and DNAm modifications are known to affect gene expression. Using a multi-omic approach, we examined differences in combined DNA methylation (DNAm) and messenger RNA (mRNA) transcriptomic data from 20 pregnant African American women (12 PTB; 8 term birth) early in pregnancy (8-18 weeks gestation). We found that the

Indexed as

Black or African AmericanPremature BirthAdolescentAdultDNA MethylationFemaleHumansMiddle AgedMultiomicsPilot ProjectsPregnancyUnited StatesYoung AdultDNA methylationepigenomeimmunologymulti-omicspreterm birthtranscriptome

Identifiers

PMID39440846
PMCPMC12127889

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.