SynthesisDiseases of the colon and rectum2025
Impact of Anastomotic Leakage After Colorectal Cancer Surgery on Quality of Life: A Systematic Review.
Synthesis in Diseases of the colon and rectum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Single-stapling versus double-stapling technique for rectal anastomosis-meta-analysis.BJS open · 2026Pooled it
- Indocyanine green fluorescence to prevent anastomotic leak in colorectal surgery: an updated systematic review and meta-analysis on randomized controlled trials.Surgical endoscopy · 2026Pooled it
- Management of anastomotic leak after elective anterior resection for rectal cancer: A systematic review and pooled analysis.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Pooled it
- Short- and Long-term Outcomes of 3-Row Vs 2-Row Circular Staplers for Low Colorectal Anastomosis After Total Mesorectal Excision: A Single-Center, Randomized, Single-Blind, Phase III Trial (THREESTAPLER Study).Diseases of the colon and rectum · 2026Trial
- Costs and health burden of surgical site infections and anastomotic leakage in major abdominal surgery.BJS open · 2026Trial
- Factors Associated with Severe Postoperative Complications (Clavien-Dindo Grades III-IV) After Left-Sided Colon Cancer Surgery: A Single-Centre Retrospective Cohort Study.Life (Basel, Switzerland) · 2026Article
- Clinical Burden of Anastomotic Leak After Elective Colorectal Cancer Surgery: A Multicenter Cohort Study.Journal of clinical medicine · 2026Article
- Structured robotic colorectal training in a non-tertiary NHS hospital: a 502-case consecutive cohort implementation study.Journal of robotic surgery · 2026Article
- Anastomotic reinforcement in rectal surgery: a position statement from an expert panel of colorectal surgeons.Updates in surgery · 2026Article
- Management of anastomotic leak following restorative rectal cancer resection-a multi-centre retrospective audit in Ireland.Irish journal of medical science · 2026Article
- Omentoplasty to Prevent Anastomotic Leak in Colorectal Anastomosis: A Systematic Review and Meta-Analysis.Cureus · 2026Review
- Quality of Life Analysis in SRC + HIPEC Patients: Single-Center Experience.Journal of clinical medicine · 2026Article
- Diagnostic accuracy of C-reactive protein in detecting anastomotic leakage after minimally invasive rectal cancer surgery.Surgical endoscopy · 2026Article
- Article
- Multimodal biomarker panel for early prediction of anastomotic leak after colorectal surgery: from inflammation to ischemia.Frontiers in surgery · 2026Review
- Mechanomedicine in digestive surgery: a theranostic framework integrating mechanical diagnostics and therapeutic modulation across the perioperative continuum.Theranostics · 2026Review
- Taming colonic anastomotic leakage: Wisdom from the ancient Chinese legend of Yu the Great.World journal of gastrointestinal surgery · 2025Article
- Construction and external validation of a predictive model for permanent stoma after sphincter-preserving surgery for rectal cancer.BMC surgery · 2025Article
- Article
- A Novel Deep Learning Model for Predicting Colorectal Anastomotic Leakage: A Pioneer Multicenter Transatlantic Study.Journal of clinical medicine · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundColorectal anastomotic leakage remains one of the most frequent and dreaded postoperative complications after colorectal resection. However, limited research has been conducted on the impact of this complication on the quality of life of patients who have undergone colorectal cancer surgery.
objectiveThe aim of this systematic review was to identify, appraise, and synthesize the available evidence regarding the quality of life in patients with anastomotic leakage after oncological colorectal resections to inform clinical decision-making. DATA SOURCES AND STUDY SELECTION: PubMed, Embase, and the Cochrane Library were searched for studies reporting quality of life using validated questionnaires in patients with anastomotic leakage after oncological colorectal resections. The literature search was performed systematically and according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. OUTCOMES: Outcomes from quality-of-life questionnaires of patients with and without anastomotic leakage were analyzed.
resultsThirteen articles reporting on 4618 individual patients were included, among which 527 patients developed anastomotic leakage. Quality of life was evaluated using 10 distinct questionnaires administered at various postoperative time points, ranging from 1 month to 14 years. Quality-of-life outcomes differed across studies and time points, but overall scores were most negatively affected by anastomotic leakage up to 12 months postoperatively. LIMITATIONS: There was a high heterogeneity between the included studies based on the questionnaires used and the time of assessment.
conclusionsThe published evidence suggests that anastomotic leakage after oncologic colorectal resection is associated with impaired quality of life, especially within the first postoperative year. The impact of anastomotic leakage on quality of life warrants further evaluation and discussion with patients.
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