Risk factors associated with antibiotic prescriptions for cases of enteric pathogens in Canada, 2015-2019.

Brendan Dougherty, Rita Finley, Danielle Dumoulin, J Scott Weese, Sherilee Harper, E Jane Parmley, Andrew Papadopoulos

Abstract read

In one paragraph

Article in Epidemiology and infection, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Brendan DoughertyDepartment of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.ORCID 0000-0002-0400-5795

Rita FinleyHealth Canada, Healthy Environments and Consumer Safety Branch, Safe Environments Directorate, Guelph, ON, Canada.

Danielle DumoulinCentre for Food-Borne, Environmental & Zoonotic Infectious Diseases, Food-Borne Disease and Antimicrobial Resistance Surveillance Division, Public Health Agency of Canada, Guelph, ON, Canada.

J Scott WeeseDepartment of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.

Sherilee HarperSchool of Public Health, University of Alberta, Edmonton, AB, Canada.

E Jane ParmleyDepartment of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.ORCID 0000-0003-4526-9524

Andrew PapadopoulosDepartment of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.

Funding

Ontario Veterinary College, University of GuelphPublic Health Agency of Canada

6 · The paper itself

Abstract

Inappropriate antibiotic use is a key driver of antibiotic resistance and one that can be mitigated through stewardship. A better understanding of current prescribing practices is needed to develop successful stewardship efforts. This study aims to identify factors that are associated with human cases of enteric illness receiving an antibiotic prescription. Cases of laboratory-confirmed enteric illness reported to the FoodNet Canada surveillance system between 2015 and 2019 were the subjects of this study. Laboratory data were combined with self-reported data collected from an enhanced case questionnaire that included demographic data, illness duration and symptoms, and antibiotic prescribing. The data were used to build univariable logistic regression models and a multivariable logistic regression model to explore what factors were associated with a case receiving an antibiotic prescription. The final multivariable model identified several factors as being significantly associated with cases being prescribed an antibiotic. Some of the identified associations indicate that current antibiotic prescribing practices include a substantial level of inappropriate use. This study provides evidence that antibiotic stewardship initiatives targeting infectious diarrhoea are needed to optimize antibiotic use and combat the rise of antibiotic resistance.

Indexed as

Anti-Bacterial AgentsAdolescentAdultAgedAged, 80 and overAntimicrobial StewardshipCanadaChildChild, PreschoolDiarrheaDrug PrescriptionsFemaleHumansInfantInfant, NewbornMaleAnti-Bacterial Agentsantibiotic prescribing practicesantibiotic resistanceantibioticsantimicrobial stewardshipfood-borne infectionssurveillance system

Identifiers

PMID39440529

DOI10.1017/S0950268824001365

PMCPMC11502423

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.