ArticleHypertension (Dallas, Tex. : 1979)2025
Increased TRPV4 Channel Expression Enhances and Impairs Blood Vessel Function in Hypertension.
Article in Hypertension (Dallas, Tex. : 1979), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- The Mechano-Immune-Vascular Activation Loop: An Integrative Conceptual Framework for Positive Feedback in Hypertension.International journal of molecular sciences · 2026Review
- Potential role of theFrontiers in genetics · 2026Article
- Transient Receptor Potential Vanilloid 4 (TRPV4) in the Human Carotid Body.International journal of molecular sciences · 2025Article
- VasoTracker 2: Open-source software and hardware for tracking blood vessel diameter and assessing vascular function.The Journal of physiology · 2025Article
- Mitochondrial Transport Proteins in Cardiovascular Diseases: Metabolic Gatekeepers, Pathogenic Mediators and Therapeutic Targets.International journal of molecular sciences · 2025Review
- Effects of SGLT2 inhibitors on ion channels in heart failure: focus on the endothelium.Basic research in cardiology · 2025Review
- Endothelial Cell TRPV4 Channels Turn to the Dark Side During Hypertension.Hypertension (Dallas, Tex. : 1979) · 2025Article
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7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndothelial cell TRPV4 (transient receptor potential vanilloid 4) channels provide a control point that is pivotal in regulating blood vessel diameter by mediating the Ca
methodsHere, using a comprehensive array of methodologies, endothelial TRPV4 channel function was examined in intact mesenteric resistance arteries from normotensive Wistar-Kyoto and spontaneously hypertensive rats.
resultsOur results show there is a notable shift in vascular reactivity in hypertension characterized by enhanced endothelium-dependent vasodilation at low levels of TRPV4 channel activation. However, at higher levels of TRPV4 activity, this vasodilatory response is reversed, contributing to the aberrant vascular tone observed in hypertension. The change in response, from dilation to constriction, was accompanied by a shift in intracellular Ca
conclusionsThese data highlight the intricate interplay between endothelial TRPV4 channel expression, intracellular Ca
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