Evidence map›Paper›PMID 39440411›Full record

ArticleJournal of agromedicine2025

Hypertonic Saline Nasal Rinse Intervention: Immunomodulatory Effects in Dairy Workers.

Grant Erlandson, Sheryl Magzamen, Julia L Sharp, James Seidel, Jill A Poole, Mary Bradford, Joshua W Schaeffer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of agromedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Grant ErlandsonDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA.
Sheryl MagzamenDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA.
Julia L SharpDepartment of Human Development and Family Studies, Colorado State University, Fort Collins, CO, USA.
James SeidelDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA.
Jill A PooleDepartment of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Mary BradfordDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA.
Joshua W SchaefferDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA.

Funding

NIOSH CDC HHS R01 OH012045NIOSH CDC HHS U01 OH010840
6 · The paper itself

Abstract

objectiveIncreased risk of occupational exposure to bioaerosols has long been recognized in livestock operations including dairy facilities. Spanning the inhalable fraction (0-100 μm), dairy bioaerosols comprise a wide variety of inflammatory components that deposit in the nasopharyngeal region. The resultant inflammatory response from bioaerosol exposure is likely driving the increased prevalence of respiratory disease observed in dairy workers. It is also thought the microbiome of the upper respiratory system may help mediate this inflammation. We investigated the viability of a low-cost hypertonic saline nasal rinse intervention in modulating inflammatory responses in bioaerosol exposed dairy workers and its impact on microbial diversity.

methodsPre- and post-shift nasal rinses were administered and collected alongside full shift inhalable personal breathing zone (PBZ) samples for each participant for up to 5 consecutive days. Treatment group participants (

resultsPM and endotoxin concentrations were comparable between groups indicating similar exposures. Post-shift pro-inflammatory markers were significantly higher than pre-shift for IL-13 (

conclusionThis study provided encouraging results that warrant future research to further evaluate saline nasal rinses as a workplace intervention.

Indexed as

DairyingOccupational ExposureAdultAerosolsEndotoxinsFemaleHumansMaleMicrobiotaMiddle AgedNasal LavageParticulate MatterSaline Solution, HypertonicAerosolsEndotoxinsParticulate MatterSaline Solution, HypertonicAgricultural healthbioaerosolsinflammationinterventionnasal lavage

Identifiers

PMID39440411
PMCPMC12165301

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.