Evidence map›Paper›PMID 39440150›Full record

ArticleNeurotrauma reports2024

The Effect of Early Beta-Blockade with Esmolol on Therapy Intensity Level in Adults with Severe Traumatic Brain Injury.

Thomas Baumer, George Higginbotham, Kati Hayes, Matt Thomas, EBB-TBI Investigators

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotrauma reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Thomas BaumerSpecialist Registrar in Intensive Care Medicine, Southmead Hospital, North Bristol NHS Trust, Bristol, UK.
George HigginbothamAcademic Foundation Doctor, Southmead Hospital, North Bristol NHS Trust, Bristol, UK.
Kati HayesResearch Nurse, Southmead Hospital, North Bristol NHS Trust, Bristol, UK.
Matt ThomasConsultant in Intensive Care Medicine, Southmead Hospital, North Bristol NHS Trust, Bristol, UK.ORCID https://orcid.org/0000-0002-3407-6762
EBB-TBI Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Following severe traumatic brain injury (TBI), elevated catecholamine levels are associated with worsened secondary brain injury and poorer clinical outcomes. The mechanisms are uncertain but may include cerebral ischemia and blood-brain barrier disruption, with consequent cerebral edema manifesting as intracranial hypertension. Early beta-blockade (EBB) may mitigate these detrimental hyperadrenergic effects. Therapy Intensity Level (TIL) is a validated score that quantifies intracranial pressure (ICP)-lowering interventions, with higher TIL being a surrogate for more severe intracranial hypertension. In this

Indexed as

beta-blockadecerebral edemaesmololintensive care unitintracranial pressuretraumatic brain injury

Identifiers

PMID39440150
PMCPMC11491576

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.