Evidence map›Paper›PMID 39440069›Full record

SynthesisF1000Research2024

The safety and efficacy of spray cryotherapy after endoscopic sinus surgery in chronic rhinosinusitis: A systematic review of randomized controlled trials.

Mohammad J J Taha, Obaida Falah, Mohammad T Abuawwad, Ayham R Sara, Adham A Aljariri, Abdulqadir J Nashwan, Ibrahim T Abuawwad, Ahmad J Taha, Abdullah A Elhakim, Majed Akili

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in F1000Research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mohammad J J TahaDepartment of Clinical Medicine, Kasr Alainy Faculty of Medicine, Cairo University, Giza, Giza Governorate, 112631, Egypt.
Obaida FalahDepartment of Clinical Medicine, Kasr Alainy Faculty of Medicine, Cairo University, Giza, Giza Governorate, 112631, Egypt.ORCID 0000-0001-8546-9059
Mohammad T AbuawwadDepartment of Clinical Medicine, Kasr Alainy Faculty of Medicine, Cairo University, Giza, Giza Governorate, 112631, Egypt.ORCID 0000-0002-2703-0942
Ayham R SaraDepartment of Clinical Medicine, Kasr Alainy Faculty of Medicine, Cairo University, Giza, Giza Governorate, 112631, Egypt.ORCID 0009-0004-2955-2420
Adham A AljaririOtolaryngology Department, Hamad Medical Corporation, Doha, 3050, Qatar.
Abdulqadir J NashwanNursing Department, Hazm Mebaireek General Hospital, Hamad Medical Corporation, Doha, 3050, Qatar.ORCID 0000-0003-4845-4119
Ibrahim T AbuawwadDepartment of Clinical Medicine, Kasr Alainy Faculty of Medicine, Cairo University, Giza, Giza Governorate, 112631, Egypt.
Ahmad J TahaDepartment of Clinical Medicine, Kasr Alainy Faculty of Medicine, Cairo University, Giza, Giza Governorate, 112631, Egypt.
Abdullah A ElhakimDepartment of Clinical Medicine, Kasr Alainy Faculty of Medicine, Cairo University, Giza, Giza Governorate, 112631, Egypt.
Majed AkiliDepartment of Clinical Medicine, Kasr Alainy Faculty of Medicine, Cairo University, Giza, Giza Governorate, 112631, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chronic rhinosinusitis (CRS) is a condition that affects 5-12% of the general population. Endoscopic sinus surgery (ESS) is the preferred treatment because of its few adverse effects and highest success rates. The most common post-operative consequences include synechia, nasal blockage, and disease recurrence. Spray cryotherapy is a novel therapeutic approach with promising outcomes for the treatment of upper airway disorders.This review aimed to investigate the effects of spray cryotherapy (SCT) following ESS in patients with chronic rhinosinusitis. Methods: Six electronic databases were searched for randomized clinical trials (RCTs). The selected trials were evaluated for methodological quality, and data were extracted by two independent reviewers. The Cochrane risk-of-bias tool was used to assess the quality of evidence. Results: Three RCTs with 85 patients were included in the final analysis. SCT was related to -16 and -77 reductions in Lund-McKay and SNOT-22 scores after 36 weeks of follow-up, in contrast to a placebo, which showed -10.4, -65. Regarding the side effects of SCT, no adverse effects were reported, and visual assessments showed no pain, visual field loss, or any other ocular complications. Conclusions: SCT is a new treatment modality after endoscopic sinus surgery that shows an effective post-operative management strategy with better post-operative scales (Lund-McKay, SNOT-22, POSE, and Lund-Kennedy) and less edema, obstruction, crusting, and inflammation with minimal or no side effects. However, further research with longer follow-ups, a larger sample size, and subjective assessment is needed to assess any possible long-term side effects.

Indexed as

CryotherapyEndoscopyRandomized Controlled Trials as TopicRhinitisSinusitisChronic DiseaseHumansParanasal SinusesRhinosinusitisTreatment Outcomechronic rhinosinusitisfunctional endoscopic sinus surgerymiddle meatus antrostomynasal polyposisspray cryotherapy

Identifiers

PMID39440069
PMCPMC11494270

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.