Evidence map›Paper›PMID 39440004›Full record

ArticleFrontiers in cellular neuroscience2024

Organoid intelligence for developmental neurotoxicity testing.

Dowlette-Mary Alam El Din, Jeongwon Shin, Alexandra Lysinger, Matthew J Roos, Erik C Johnson, Timothy J Shafer, Thomas Hartung, Lena Smirnova

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dowlette-Mary Alam El DinCenter for Alternatives to Animal Testing, Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States.
Jeongwon ShinDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States.
Alexandra LysingerCenter for Alternatives to Animal Testing, Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States.
Matthew J RoosResearch and Exploratory Development Department, Johns Hopkins University Applied Physics Laboratory, Laurel, MD, United States.
Erik C JohnsonResearch and Exploratory Development Department, Johns Hopkins University Applied Physics Laboratory, Laurel, MD, United States.
Timothy J ShaferCenter for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, United States.
Thomas HartungCenter for Alternatives to Animal Testing, Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States.
Lena SmirnovaCenter for Alternatives to Animal Testing, Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States.

Funding

Traning Program in Environmental Health SciencesT32ES007141 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI Marsha Wills-Karp · 1985 to 2026
$22.2M
GEARs Combining advances in Genomics and Environmental science to accelerate Actionable Research and practice in ASDR01ES034554 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI Christine Ladd-Acosta, HEATHER E VOLK · 2022 to 2026
$9.7M
Pilot Project ProgramP30ES032756 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI Marsha Wills-Karp · 2022 to 2026
$6.0M
NIEHS NIH HHS P30 ES032756NIEHS NIH HHS R01 ES034554NIEHS NIH HHS T32 ES007141
6 · The paper itself

Abstract

The increasing prevalence of neurodevelopmental disorders has highlighted the need for improved testing methods to determine developmental neurotoxicity (DNT) hazard for thousands of chemicals. This paper proposes the integration of organoid intelligence (OI); leveraging brain organoids to study neuroplasticity

Indexed as

artificial intelligencedevelopmental neurotoxicitymachine learningorganoidorganoid intelligencesynaptic plasiticity

Identifiers

PMID39440004
PMCPMC11493634

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.