Evidence map›Paper›PMID 39439897›Full record

ArticleFrontiers in pharmacology2024

FOXO1-mediated autophagy regulation by miR-223 in sepsis-induced immunosuppression.

Guoan Xiang, Qi Li, Di Lian, Chengcheng Su, Xin Li, Shoulong Deng, Lixin Xie

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Research progress on the mechanism of FOXO protein in sepsis.Apoptosis : an international journal on programmed cell death · 2026
    Review
  3. Review
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Guoan Xiang *College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China.
Qi Li *Department of Tuberculosis, Beijing Chest Hospital, Capital Medical University, Beijing, China.
Di Lian *College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China.
Chengcheng SuDepartment of Respiratory and Critical Care Medicine, Pingjin Hospital, Characteristic Medical Center of the Chinese People's Armed Police Force, Tianjin, China.
Xin LiDepartment of Emergency, Third Medical Center of Chinese PLA General Hospital, Beijing, China.
Shoulong DengNational Center of Technology Innovation for Animal Model, National Human Diseases Animal Model Resource Center, National Health Commission of China (NHC) Key Laboratory of Comparative Medicine, Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China.
Lixin XieCollege of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Immunosuppression is the main cause of the high mortality rate in patients with sepsis. The decrease in the number and dysfunction of CD4 Methods: In this study, we modulate the expression of miR-223 in CD4 Results: We found that when the expression of miR-223 increased, FOXO1 expression decreased and autophagy decreased; whereas, when FOXO1 expression was inhibited, autophagy decreased significantly in different cell models after LPS induction. Conclusion: Thus, this study proved that miR-223 participate in the regulation of LPS-induced autophagy via the regulation of FOXO1 expression in CD4

Indexed as

autophagyCD4+ T lymphocytesFOXO1immunosuppressionmiR-223sepsis

Identifiers

PMID39439897
PMCPMC11493625

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.