Evidence map›Paper›PMID 39439795›Full record

Observational studyFrontiers in immunology2024

Genetic signatures of

Ingrid Marins de Almeida, Bruna Ramos Tosta, Laiane da Cruz Pena, Hatilla Dos Santos Silva, Fabiane S Reis-Goes, Nívia N Silva, João Victor Andrade Cruz, Mailane Dos Anjos Silva, Jéssica Francisco de Araújo, Juliana Lopes Rodrigues and 15 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Ingrid Marins de AlmeidaLaboratório de Imunofarmacologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil.
Bruna Ramos TostaLaboratório de Imunofarmacologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil.
Laiane da Cruz PenaLaboratório de Imunofarmacologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil.
Hatilla Dos Santos SilvaLaboratório de Imunofarmacologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil.
Fabiane S Reis-GoesLaboratório de Imunologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil.
Nívia N SilvaLaboratório de Imunologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil.
João Victor Andrade CruzLaboratório de Imunofarmacologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil.
Mailane Dos Anjos SilvaLaboratório de Imunofarmacologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil.
Jéssica Francisco de AraújoLaboratório de Imunofarmacologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil.
Juliana Lopes RodriguesLaboratório de Imunofarmacologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil.
Gabriella OliveiraLaboratório de Análises Clínicas, Instituto Couto Maia, Salvador, Brazil.
Ricardo Gassmann FigueiredoUniversidade Estadual de Feira de Santana, Feira de Santana, Brazil.
Sara Nunes VazHospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil.
Iris Montaño-CastellónHospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil.
Daniele SantanaHospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil.
Alex TorresLaboratório de Imunologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil.
Fabyan Esberard de Lima BeltrãoHospital Universitário Lauro Wanderley, Universidade Federal da Paraíba, João Pessoa, Brazil.
Valdirene Leão CarneiroDepartamento de Ciências da Vida, Universidade do Estado da Bahia, Salvador, Brazil.
Gubio Soares CamposLaboratório de Virologia, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil.
Carlos BritesHospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil.
Vitor FortunaLaboratório de Imunologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil.
Camila Alexandrina FigueiredoLaboratório de Imunofarmacologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil.
Soraya Castro TrindadeLaboratório de Imunologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil.
Helton Estrela RamosPrograma de Pós-Graduação em Processos Interativos de Órgãos e Sistema, Instituto de Saúde e Ciência, Universidade Federal da Bahia, Salvador, Brazil.
Ryan Dos Santos CostaLaboratório de Imunofarmacologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The COVID-19, triggered by the SARS-CoV-2 virus, has varied clinical manifestations, ranging from mild cases to severe forms such as fatal pneumonia and acute respiratory distress syndrome (ARDS). Disease severity is influenced by an exacerbated immune response, characterized by high pro-inflammatory cytokine levels. Inhibition of AKT can potentially suppress pathological inflammation, cytokine storm and platelet activation associated with COVID-19. In this study, we aimed to investigate the rs2494746 and rs1130214 variants in the Methods: Peripheral blood samples and sociodemographic data from 508 individuals with COVID-19, measuring plasma cytokine concentrations using ELISA and genotyped the Results: The rs2494746-C allele was associated with severity, ICU admission, and death from COVID-19. The C allele at rs1130214 was linked to increased TNF and D-dimer levels. Moreover, both variants exhibited an increased cumulative risk of disease severity, ICU admission, and mortality caused by COVID-19. In the predictive analysis, the rs2494746 obtained an accuracy of 71%, suggesting a high probability of the test determining the severity of the disease. Discussion: Our findings contribute to understanding the influence of the

Indexed as

COVID-19Proto-Oncogene Proteins c-aktSARS-CoV-2Severity of Illness IndexAdultAgedCytokinesFemaleFibrin Fibrinogen Degradation ProductsHumansMaleMiddle AgedPolymorphism, Single NucleotideAKT1 protein, humanCytokinesFibrin Fibrinogen Degradation Productsfibrin fragment DProto-Oncogene Proteins c-aktAKT1COVID-19immunogeneticspolymorphismseverity

Identifiers

PMID39439795
PMCPMC11493623

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.