Evidence map›Paper›PMID 39439564›Full record

ReviewFrontiers in endocrinology2024

The emerging modulators of non-coding RNAs in diabetic wound healing.

Sis Aghayants, Jinjin Zhu, Jing Yu, Rui Tao, Sicheng Li, Shengzhi Zhou, Yunhua Zhou, Zhanyong Zhu

Abstract readReview
In one paragraph

Review in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Recent Advances in the Application of Cucurbitacin B as an Anticancer Agent.International journal of molecular sciences · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sis Aghayants *Department of Plastic Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Jinjin Zhu *Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, China.
Jing Yu *Department of Plastic and Cosmetic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Rui TaoDepartment of Plastic Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Sicheng LiDepartment of Plastic Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Shengzhi ZhouDepartment of Plastic Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Yunhua ZhouDepartment of Wound Repair Surgery, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Zhanyong ZhuDepartment of Plastic Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic wound healing is a complex physiological process often hindered by the underlying metabolic dysfunctions associated with diabetes. Despite existing treatments, there remains a critical need to explore innovative therapeutic strategies to improve patient outcomes. This article comprehensively examines the roles of non-coding RNAs (ncRNAs), specifically microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), in regulating key phases of the wound healing process: inflammation, angiogenesis, re-epithelialization, and tissue remodeling. Through a deep review of current literature, we discuss recent discoveries of ncRNAs that have been shown to either promote or impair the wound healing process in diabetic wound healing, which were not covered in earlier reviews. This review highlights the specific mechanisms by which these ncRNAs impact cellular behaviors and pathways critical to each healing stage. Our findings indicate that understanding these recently identified ncRNAs provides new insights into their potential roles in diabetic wound healing, thereby contributing valuable knowledge for future research directions in this field.

Indexed as

RNA, UntranslatedWound HealingAnimalsDiabetes ComplicationsDiabetes MellitusHumansMicroRNAsRNA, CircularRNA, Long NoncodingMicroRNAsRNA, CircularRNA, Long NoncodingRNA, Untranslatedcircular RNAdiabetic foot ulcerdiabetic woundlong non-coding RNAmicroRNAnon-coding RNA

Identifiers

PMID39439564
PMCPMC11493653

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.