ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Reductions in the white-gray functional connectome in preclinical Alzheimer's disease and their associations with amyloid and cognition.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Article
- White-Matter BOLD Encoding Beyond Marginal Connectivity.bioRxiv : the preprint server for biology · 2026Article
- Contributions of the Alzheimer's Disease Neuroimaging Initiative to advancing AD research: a targeted review of recent publications.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- The nature and interpretation of BOLD signals in white matter - A review.Magnetic resonance imaging · 2026Review
- Early Microstructural Changes in the Left Inferior Fronto-Occipital Fasciculus: A Key Factor in Probable Alzheimer's Disease Patients With Slow Gait Speed.Brain and behavior · 2026Article
- Investigating white matter functional network connectivity across the Alzheimer's disease spectrum using resting-state fMRI.Frontiers in neuroimaging · 2026Article
- White-Matter BOLD Mediates Time-Varying Cortico-Cortical Functional Connectivity.bioRxiv : the preprint server for biology · 2025Article
- GWM-HFN, a Gray-White Matter heterogeneous fusion network for functional connectomes.Communications biology · 2025Article
- Investigation of the large-scale white-matter functional networks in spinocerebellar ataxia type 3.Quantitative imaging in medicine and surgery · 2025Article
- BrainVAE: Exploring the role of white matter BOLD in preclinical Alzheimer's disease classification.bioRxiv : the preprint server for biology · 2025Article
- Myelination selectively modulates BOLD signal in white matter.Research square · 2025Article
- Bundle-wise functional connectivity density and fractional amplitude of low-frequency fluctuations decrease in white matter in preclinical Alzheimer's disease and are associated with Aβ levels and cognition.Proceedings of SPIE--the International Society for Optical Engineering · 2025Article
- Reductions in the white-gray functional connectome in preclinical Alzheimer's disease and their associations with amyloid and cognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Associations between neuronavigated rTMS-mediated functional connectome plasticity and neurotransmitter receptors in Alzheimer's disease.Alzheimer's & dementia (New York, N. Y.)Article
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Authors and funding
13 authors.
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Abstract
backgroundThe magnitudes and patterns of alterations of the white-gray matter (WM-GM) functional connectome in preclinical Alzheimer's disease (AD), and their associations with amyloid and cognition, remain unclear.
methodsWe compared regional WM-GM functional connectivity (FC) and network properties in subjects with preclinical AD (or AD dementia) and controls (total n = 344). Their associations with positron emission tomography AV45-measured amyloid beta (Aβ) load and modified Preclinical Alzheimer Cognitive Composite (mPACC) scores were examined.
resultsPreclinical AD subjects showed lower FC in specific WM-GM pairs and reduced segregation of control, dorsal attention, and somatomotor networks. A major portion of the reduced FC and network segregations were linked to elevated Aβ. Reduced FC of one WM-GM pair correlated with impaired mPACC. AD dementia exhibited broader reductions and stronger associations. DISCUSSION: The WM-GM functional connectome undergoes regional and systemic dysfunctions as early as in the preclinical stage, correlating with amyloid deposition and predicting cognitive impairment. HIGHLIGHTS: Preclinical Alzheimer's disease (AD) subjects showed lower functional connectivity in specific white-gray matter (WM-GM) pairs and reduced segregations of control, dorsal attention, and somatomotor networks. A major portion of the reduced connectivity and network segregations were linked to elevated amyloid beta load. Only one WM-GM pair's reduced connectivity was linearly correlated with impaired cognitive composite scores. AD dementia showed more extensive reductions in connectivity, network integration, and segregation, with stronger associations with amyloid elevation and cognitive impairment. The WM-GM functional connectome offers a distinct perspective for understanding changes in brain functional architecture throughout the AD continuum.
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