ArticleAnimal models and experimental medicine2025
Processing-induced reduction in dianthrones content and toxicity of Polygonum multiflorum: Insights from ultra-high performance liquid chromatography triple quadrupole mass spectrometry analysis and toxicological assessment.
Article in Animal models and experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Supramolecular strategy in traditional Chinese medicine processing: Mechanistic insights mediated by self-assembly.Acta pharmaceutica Sinica. B · 2026Review
- Characterization of Antioxidant Constituents and Geographical Differentiation ofAntioxidants (Basel, Switzerland) · 2026Article
- Hepatotoxic Compounds and Mechanisms of Polygonum Multiflorum: A Narrative Review of Recent Advances.International journal of molecular sciences · 2026Review
- Processing-induced reduction in dianthrones content and toxicity of Polygonum multiflorum: Insights from ultra-high performance liquid chromatography triple quadrupole mass spectrometry analysis and toxicological assessment.Animal models and experimental medicine · 2025Article
- Emodin and physcion alleviate cholestatic liver injury by targeting FXR: hepatoprotective components identified in processedFrontiers in pharmacology · 2025Article
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Abstract
backgroundPolygonum multiflorum-induced liver injury (PM-DILI) has significantly hindered its clinical application and development.
methodsThis study investigates the variation in content and toxicity of dianthrones, the toxic components of P. multiflorum, during different processing cycles. We employed the ultra-high-performance liquid chromatography triple quadrupole mass spectrometry method to quantify six dianthrones in raw P. multiflorum and formulations processed with a method called nine cycles of steaming and sunning. Additionally, toxicity assessments were conducted using human normal liver cell line L02 and zebrafish embryos.
resultsResults indicate a gradual reduction in dianthrones content with increasing processing cycles. Processed formulations exhibited significantly reduced cytotoxicity in L02 cells and hepatotoxicity in zebrafish embryos.
conclusionsOur findings elucidate the relationship between processing cycles and P. multiflorum toxicity, providing theoretical support for its safe use.
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