Evidence map›Paper›PMID 39439002›Full record

ArticleActa neuropathologica communications2024

A minimally invasive biomarker for sensitive and accurate diagnosis of Parkinson's disease.

Zerui Wang, Tricia Gilliland, Hyun Jo Kim, Maria Gerasimenko, Kailey Sajewski, Manuel V Camacho, Gurkan Bebek, Shu G Chen, Steven A Gunzler, Qingzhong Kong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Zerui WangDepartment of Pathology, Case Western Reserve University, Cleveland, OH, 44106, USA. zxw488@case.edu.
Tricia GillilandDepartment of Pathology, Case Western Reserve University, Cleveland, OH, 44106, USA.
Hyun Jo KimCenter for Proteomics and Bioinformatics, Department of Nutrition, Case Western Reserve University, Cleveland, OH, USA.
Maria GerasimenkoDepartment of Pathology, Case Western Reserve University, Cleveland, OH, 44106, USA.
Kailey SajewskiNeurological Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, 44106, USA.
Manuel V CamachoDepartment of Pathology, Case Western Reserve University, Cleveland, OH, 44106, USA.
Gurkan BebekCenter for Proteomics and Bioinformatics, Department of Nutrition, Case Western Reserve University, Cleveland, OH, USA.
Shu G ChenDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL, 35233, USA. sgchen@uabmc.edu.
Steven A GunzlerNeurological Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, 44106, USA. Steven.Gunzler@uhhospitals.org.
Qingzhong KongDepartment of Pathology, Case Western Reserve University, Cleveland, OH, 44106, USA. qxk2@case.edu.

Funding

Peripheral Tissue Biomarker for Premorten Diagnosis of Lewy Body DementiaR01NS118760 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHEN, SHU G., KRAUS, ALLISON L · 2020 to 2025
$7.4M
Assessing skin biomarkers for preclinical diagnosis of PD and non-PD ParkinsonismU01NS112010 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI CHEN, SHU G., GUNZLER, STEVEN A. · 2019 to 2023
$3.7M
NIH HHS U01 NS112010NINDS NIH HHS R01 NS118760NINDS NIH HHS U01 NS112010
6 · The paper itself

Abstract

Seeding activities of disease-associated α-synuclein aggregates (αSyn

Indexed as

alpha-SynucleinBiomarkersParkinson DiseaseSalivaAgedFemaleHumansMaleMiddle AgedProspective StudiesSensitivity and Specificityalpha-SynucleinBiomarkersAlpha-synucleinBiomarkerParkinson’s diseaseRT-QuICSeeding activity

Identifiers

PMID39439002
PMCPMC11495072

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.