Evidence map›Paper›PMID 39438917›Full record

ArticleJournal of nanobiotechnology2024

Photoimmunotherapy using indocyanine green-loaded Codium fragile polysaccharide and chitosan nanoparticles suppresses tumor growth and metastasis.

Dayoung Ryu, Hae-Bin Park, Eun-Koung An, So-Jung Kim, Da Young Kim, Daeun Lim, Juyoung Hwang, Minseok Kwak, Wonpil Im, Ja-Hyoung Ryu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Dayoung Ryu *Department of Biochemistry and Molecular Biology, Brain Korea 21 project, University of Ulsan College of Medicine, ASAN Medical Center, Seoul, 05505, South Korea.
Hae-Bin Park *Department of Microbiology, Brain Korea 21 project, University of Ulsan College of Medicine, ASAN Medical Center, Seoul, 05505, South Korea.
Eun-Koung AnDepartment of Microbiology, Brain Korea 21 project, University of Ulsan College of Medicine, ASAN Medical Center, Seoul, 05505, South Korea.
So-Jung KimDepartment of Microbiology, Brain Korea 21 project, University of Ulsan College of Medicine, ASAN Medical Center, Seoul, 05505, South Korea.
Da Young KimDepartment of Microbiology, Brain Korea 21 project, University of Ulsan College of Medicine, ASAN Medical Center, Seoul, 05505, South Korea.
Daeun LimDepartment of Microbiology, Brain Korea 21 project, University of Ulsan College of Medicine, ASAN Medical Center, Seoul, 05505, South Korea.
Juyoung HwangDepartment of Chemistry, Pukyong National University, Busan, 48513, South Korea.
Minseok KwakDepartment of Chemistry, Pukyong National University, Busan, 48513, South Korea.
Wonpil ImDepartments of Biological Sciences, Lehigh University, Bethlehem, PA, USA.
Ja-Hyoung RyuDepartment of Chemistry, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, South Korea.
SangGuan YouDepartment of Marine Food Science and Technology, Gangneung-Wonju National University, 120 Gangneung Daehangno, Gangneung, Gangwon, 210-702, South Korea. umyousg@gwnu.ac.kr.
Peter C W LeeDepartment of Biochemistry and Molecular Biology, Brain Korea 21 project, University of Ulsan College of Medicine, ASAN Medical Center, Seoul, 05505, South Korea. pclee@amc.seoul.kr.
Jun-O JinDepartment of Microbiology, Brain Korea 21 project, University of Ulsan College of Medicine, ASAN Medical Center, Seoul, 05505, South Korea. junojin@amc.seoul.kr.

Funding

Asan Medical Center 2023IP0126National Research Foundation of Korea RS-2023-00207868
6 · The paper itself

Abstract

Metastasis and recurrence are the main challenges in cancer treatment. Among various therapeutic approaches, immunotherapy holds promise for preventing metastasis and recurrence. In this study, we evaluated the efficacy of treating primary cancer and blocking metastasis and recurrence with photo-immunotherapeutic nanoparticles, which were synthesized using two types of charged polysaccharides. Codium fragile polysaccharide (CFP), which exhibits immune-stimulating properties and carries a negative charge, was combined with positively charged chitosan to synthesize nanoparticles. Additionally, indocyanine green (ICG), a photosensitizer, was loaded inside these particles and was referred to as chitosan-CFP-ICG (CC-ICG). Murine colon cancer cells (CT-26) internalized CC-ICG, and subsequent 808-nanometer laser irradiation promoted apoptotic/necrotic cell death. Moreover, intratumoral injection of CC-ICG, with 808-nanometer laser irradiation eliminated CT-26 tumors in mice. Rechallenged lung metastases of CT-26 cancer were inhibited by dendritic cell activation-mediated cytotoxic T lymphocyte stimulation in mice cured by CC-ICG. These results demonstrated that CC-ICG is a natural tumor therapeutic with the potential to treat primary tumors and suppress metastasis and recurrence.

Indexed as

ChitosanImmunotherapyIndocyanine GreenMice, Inbred BALB CNanoparticlesPolysaccharidesAnimalsCell Line, TumorColonic NeoplasmsFemaleLung NeoplasmsMiceNeoplasm MetastasisPhotosensitizing AgentsPhototherapyChitosanIndocyanine GreenPhotosensitizing AgentsPolysaccharidesChitosanCodium fragile polysaccharideLung metastasisNanoparticlePhotoimmunotherapy

Identifiers

PMID39438917
PMCPMC11515802

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.