Evidence map›Paper›PMID 39438891›Full record

ReviewCancer imaging : the official publication of the International Cancer Imaging Society2024

Current trends in the characterization and monitoring of vascular response to cancer therapy.

Binita Shrestha, Noah B Stern, Annie Zhou, Andrew Dunn, Tyrone Porter

Abstract readReview
In one paragraph

Review in Cancer imaging : the official publication of the International Cancer Imaging Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Imaging the hallmarks of cancer.Nature reviews. Cancer · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Monitoring Pharmacological Treatment of Breast Cancer with MRI.Current issues in molecular biology · 2025
    Review
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Binita ShresthaDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA. Binita.shrestha@utexas.edu.
Noah B SternDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.
Annie ZhouDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.
Andrew DunnDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.
Tyrone PorterDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.

Funding

Comprehensive Training Program in Imaging Science and InformaticsT32EB007507 · NIBIB · UNIVERSITY OF TEXAS AT AUSTIN · PI MARKEY, MIA K, RYLANDER, HENRY GRADY · 2009 to 2024
$2.7M
Development of Nanosensors to Image Macrophage PolarizationR56EB032211 · NIBIB · UNIVERSITY OF TEXAS AT AUSTIN · PI SUGGS, LAURA J · 2021 to 2021
$497k
NIBIB NIH HHS R56 EB032211NIBIB NIH HHS R56 EB32211-01NIBIB NIH HHS T32 EB007507
6 · The paper itself

Abstract

Tumor vascular physiology is an important determinant of disease progression as well as the therapeutic outcome of cancer treatment. Angiogenesis or the lack of it provides crucial information about the tumor's blood supply and therefore can be used as an index for cancer growth and progression. While standalone anti-angiogenic therapy demonstrated limited therapeutic benefits, its combination with chemotherapeutic agents improved the overall survival of cancer patients. This could be attributed to the effect of vascular normalization, a dynamic process that temporarily reverts abnormal vasculature to the normal phenotype maximizing the delivery and intratumor distribution of chemotherapeutic agents. Longitudinal monitoring of vascular changes following antiangiogenic therapy can indicate an optimal window for drug administration and estimate the potential outcome of treatment. This review primarily focuses on the status of various imaging modalities used for the longitudinal characterization of vascular changes before and after anti-angiogenic therapies and their clinical prospects.

Indexed as

Angiogenesis InhibitorsNeoplasmsNeovascularization, PathologicHumansAngiogenesis Inhibitors

Identifiers

PMID39438891
PMCPMC11515715

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.