Evidence map›Paper›PMID 39438691›Full record

SynthesisProstate cancer and prostatic diseases2025

Complication rate across the minimally invasive surgical treatments (MISTs): where do we stand? A systematic review of the literature.

Luca Lambertini, Alessandro Sandulli, Simone Coco, Daniele Paganelli, Anna Cadenar, Paolo Dell'Oglio, Stefano Puliatti, Fabrizio Di Maida, Antonio Andrea Grosso, Daniele Amparore and 10 more

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Prostate cancer and prostatic diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Review
  3. Risk of bone metastases on [European journal of nuclear medicine and molecular imaging · 2026
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  12. End-to-end [Abdominal radiology (New York) · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Luca LambertiniOncologic Minimally Invasive Urology and Andrology Unit, Department of Experimental and Clinical Medicine, Careggi Hospital, University of Florence, 50121, Florence, Italy.
Alessandro SandulliOncologic Minimally Invasive Urology and Andrology Unit, Department of Experimental and Clinical Medicine, Careggi Hospital, University of Florence, 50121, Florence, Italy.
Simone CocoOncologic Minimally Invasive Urology and Andrology Unit, Department of Experimental and Clinical Medicine, Careggi Hospital, University of Florence, 50121, Florence, Italy.
Daniele PaganelliOncologic Minimally Invasive Urology and Andrology Unit, Department of Experimental and Clinical Medicine, Careggi Hospital, University of Florence, 50121, Florence, Italy.
Anna CadenarOncologic Minimally Invasive Urology and Andrology Unit, Department of Experimental and Clinical Medicine, Careggi Hospital, University of Florence, 50121, Florence, Italy.
Paolo Dell'OglioDepartment of Urology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Stefano PuliattiDepartment of Urology, University of Modena and Reggio Emilia, Modena, Italy.ORCID 0000-0002-1597-9595
Fabrizio Di MaidaOncologic Minimally Invasive Urology and Andrology Unit, Department of Experimental and Clinical Medicine, Careggi Hospital, University of Florence, 50121, Florence, Italy.ORCID 0000-0003-1885-4808
Antonio Andrea GrossoOncologic Minimally Invasive Urology and Andrology Unit, Department of Experimental and Clinical Medicine, Careggi Hospital, University of Florence, 50121, Florence, Italy.ORCID 0000-0001-5973-789X
Daniele AmparoreUniversity of Turin San Luigi Gonzaga Hospital, Division of Urology, Turin, Italy.ORCID 0000-0001-5425-5453
Riccardo BertoloDepartment of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.ORCID 0000-0003-0260-4601
Riccardo CampiDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy; Unit of Urological Robotic Surgery and Renal Transplantation, University of Florence, Careggi Hospital, Florence, Italy.ORCID 0000-0001-5237-0888
Riccardo LombardoDepartment of Urology, Sant'Andrea Hospital, Sapienza University, Rome, Italy.ORCID 0000-0003-2890-3159
Matteo FerroUnit of Urology, Department of Health Science, University of Milan, ASST Santi Paolo and Carlo, Milan, Italy.
Bernardo RoccoUnit of Urology, Department of Health Science, University of Milan, ASST Santi Paolo and Carlo, Milan, Italy.
Gianni VittoriOncologic Minimally Invasive Urology and Andrology Unit, Department of Experimental and Clinical Medicine, Careggi Hospital, University of Florence, 50121, Florence, Italy.
Alessandro AntonelliDepartment of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.ORCID 0000-0002-7455-8803
Cosimo De NunzioDepartment of Urology, Sant'Andrea Hospital, Sapienza University, Rome, Italy.ORCID 0000-0002-2190-512X
Andrea MinerviniOncologic Minimally Invasive Urology and Andrology Unit, Department of Experimental and Clinical Medicine, Careggi Hospital, University of Florence, 50121, Florence, Italy.
Andrea MariOncologic Minimally Invasive Urology and Andrology Unit, Department of Experimental and Clinical Medicine, Careggi Hospital, University of Florence, 50121, Florence, Italy. andrea.mari@unifi.it.ORCID 0000-0001-9070-5706

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOver the past decade, the range of surgical options to benign prostatic obstruction (BPO) has expanded significantly with the advent of minimally invasive surgical therapies (MISTs). Nevertheless, the available evidence in the field is heterogeneous. Efficacy and safety thresholds are yet to be determined.

objectiveTo evaluate perioperative and long-term complications after MISTs - including Aquablation, steam injection (Rezūm), Transperineal laser ablation of the prostate (TPLA), implantation of a prostatic urethral lift (PUL) and temporary implantable nitinol device (iTIND) - in patients with lower urinary tract symptoms due to BPO. EVIDENCE ACQUISITION: A systematic literature search was conducted in January 2024 using Medline (via PubMed), Embase (via Ovid), Scopus, and Web of Science. The search strategy used PICO criteria (Patients, Interventions, Comparisons, Outcomes) [1], focusing specifically on patients with BPH-associated LUTS who underwent MIST or other comparative treatments, aiming to assess both perioperative and long-term safety outcomes. Article selection was conducted in accordance with the PRISMA guidelines. The risk of bias and the quality of the articles included were assessed. A dedicated data extraction form was used to collect the data of interest. EVIDENCE SYNTHESIS: The initial electronic search identified 3660 records, of which 24 ultimately met the inclusion criteria and were included in the analysis. Overall, Aquablation was associated with a higher major complications rate of 14% (IQR 6-22), particularly in the case of patients with prostates <70 ml. PUL showed a higher early postoperative acute urinary retention rate (10.9%, IQR 9.2-12.3%), while 1.4% of patients treated with iTIND experienced major perioperative complications. Urinary tract infections were mostly reported in series assessing TPLA and Rezūm.

conclusionsThe adoption of MISTs for LUTS due to BPH is associated with a varied spectrum of perioperative and long-term complications. Our findings showed an acceptable safety profile with specific complications dependent on the type of MIST performed, highlighting the importance of individualized patient selection and procedure-specific considerations.

Indexed as

Lower Urinary Tract SymptomsMinimally Invasive Surgical ProceduresPostoperative ComplicationsProstatectomyProstatic HyperplasiaHumansMale

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.