Evidence map›Paper›PMID 39438623›Full record

ArticleNature cancer2024

Selenocysteine tRNA methylation promotes oxidative stress resistance in melanoma metastasis.

Leona A Nease, Kellsey P Church, Ines Delclaux, Shino Murakami, Maider Astorkia, Marwa Zerhouni, Graciela Cascio, Riley O Hughes, Kelsey N Aguirre, Paul Zumbo and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
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  12. Article
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  14. Decoding the role of tRNA modifications in cancer progression.Current opinion in genetics & development · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Leona A NeaseSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Kellsey P ChurchSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Ines DelclauxSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0009-0001-6420-2934
Shino MurakamiDepartment of Pharmacology, Weill Cornell Medicine, New York, NY, USA.
Maider AstorkiaApplied Bioinformatics Core, Weill Cornell Medicine, New York, NY, USA.
Marwa ZerhouniSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Graciela CascioSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Riley O HughesSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-2480-9125
Kelsey N AguirreSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-9828-6355
Paul ZumboApplied Bioinformatics Core, Weill Cornell Medicine, New York, NY, USA.
Lukas E DowSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-7048-1418
Samie JaffreyDepartment of Pharmacology, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-3615-6958
Doron BetelApplied Bioinformatics Core, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-8006-7752
Elena PiskounovaSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA. elp2025@med.cornell.edu.ORCID http://orcid.org/0000-0002-8554-8475

Funding

Predoctoral Training in Pharmacological SciencesT32GM141949 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Kristen Elizabeth Pleil · 2021 to 2026
$2.5M
Regulation of the Selenocysteine Stress Response in Cancer MetastasisF31CA254235 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI NEASE, LEONA · 2020 to 2022
$138k
NIGMS NIH HHS T32 GM141949U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) F31 CA 254235
6 · The paper itself

Abstract

Selenocysteine-containing proteins play a central role in redox homeostasis. Their translation is a highly regulated process and is dependent on two tRNA

Indexed as

MelanomaOxidative StressAnimalsCell Line, TumorHumansMethylationMethyltransferasesMiceNeoplasm MetastasisProtein BiosynthesisRNA, Transfer, Amino Acid-SpecificSelenoproteinsMethyltransferasesRNA, Transfer, Amino Acid-SpecificSelenoproteinstRNA, selenocysteine-

Identifiers

PMID39438623

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.