ArticleTranslational psychiatry2024
Resting-state brain activation patterns and network topology distinguish human sign and goal trackers.
Article in Translational psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Reproducible human reward imaging phenotypes exhibit differential sensitivity to dopamine D2 receptor antagonism.Nature communications · 2026Article
- Can the incentive-sensitization theory of addiction incorporate addiction to opioid drugs?Psychopharmacology · 2026Review
- Connectome-based predictive modeling of concurrent and longitudinal substance use vulnerability in adolescence.Developmental cognitive neuroscience · 2026Article
- Test-retest reliability of the gaze index for sign-tracking and goal-tracking.Behavior research methods · 2026Article
- Article
- Motivation, attention, and uncertainty: insights from animal and human research and implications for addiction.Frontiers in psychology · 2026Review
- Connectome-Based Predictive Modeling of Concurrent and Prospective Substance Use in Adolescence.bioRxiv : the preprint server for biology · 2025Article
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Authors and funding
9 authors.
Funding
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Abstract
The "Sign-tracker/Goal-tracker" (ST/GT) is an animal model of individual differences in learning and motivational processes attributable to distinctive conditioned responses to environmental cues. While GT rats value the reward-predictive cue as a mere predictor, ST rats attribute it with incentive salience, engaging in aberrant reward-seeking behaviors that mirror those of impulse control disorders. Given its potential clinical value, the present study aimed to map such model onto humans and investigated resting state functional magnetic resonance imaging correlates of individuals categorized as more disposed to sign-tracking or goal-tracking behavior. To do so, eye-tracking was used during a translationally informed Pavlovian paradigm to classify humans as STs (n = 36) GTs (n = 35) or as Intermediates (n = 33), depending on their eye-gaze towards the reward-predictive cue or the reward location. Using connectivity and network-based approach, measures of resting state functional connectivity and centrality (role of a node as a hub) replicated preclinical findings, suggesting a major involvement of subcortical areas in STs, and dominant cortical involvement in GTs. Overall, the study strengthens the translational value of the ST/GT model, with important implications for the early identification of vulnerable phenotypes for psychopathological conditions such as substance use disorder.
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