Evidence map›Paper›PMID 39438454›Full record

ArticleNature communications2024

Data-driven fingerprint nanoelectromechanical mass spectrometry.

John E Sader, Alfredo Gomez, Adam P Neumann, Alex Nunn, Michael L Roukes

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Mechanomedicine.Nature reviews bioengineering · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

John E SaderGraduate Aerospace Laboratories, California Institute of Technology, Pasadena, California, 91125, USA. jsader@caltech.edu.ORCID http://orcid.org/0000-0002-7096-0627
Alfredo GomezDepartment of Physics, California Institute of Technology, Pasadena, California, 91125, USA.ORCID http://orcid.org/0000-0002-6116-1647
Adam P NeumannDepartment of Physics, California Institute of Technology, Pasadena, California, 91125, USA.ORCID http://orcid.org/0000-0002-2961-7640
Alex NunnDepartment of Physics, California Institute of Technology, Pasadena, California, 91125, USA.
Michael L RoukesDepartment of Applied Physics, California Institute of Technology, Pasadena, California, 91125, USA. roukes@caltech.edu.ORCID http://orcid.org/0000-0002-2916-6026

Funding

Next-generation spatial -omics: High-throughput, single-molecule proteomic imaging with subcellular resolutionR01MH136394 · NIMH · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ROUKES, MICHAEL L · 2023 to 2024
$5.9M
NIMH NIH HHS R01 MH136394Wellcome Trust
6 · The paper itself

Abstract

Fingerprint analysis is a ubiquitous tool for pattern recognition with applications spanning from geolocation and DNA analysis to facial recognition and forensic identification. Central to its utility is the ability to provide accurate identification without an a priori mathematical model for the pattern. We report a data-driven fingerprint approach for nanoelectromechanical systems mass spectrometry that enables mass measurements of particles and molecules using complex, uncharacterized nanoelectromechanical devices of arbitrary specification. Nanoelectromechanical systems mass spectrometry is based on the frequency shifts of the nanoelectromechanical device vibrational modes that are induced by analyte adsorption. The sequence of frequency shifts constitutes a fingerprint of this adsorption, which is directly amenable to pattern matching. Two current requirements of nanoelectromechanical-based mass spectrometry are: (1) a priori knowledge or measurement of the device mode-shapes, and (2) a mode-shape-based model that connects the induced modal frequency shifts to mass adsorption. This may not be possible for advanced nanoelectromechanical devices with three-dimensional mode-shapes and nanometer-sized features. The advance reported here eliminates this impediment, thereby allowing device designs of arbitrary specification and size to be employed. This enables the use of advanced nanoelectromechanical devices with complex vibrational modes, which offer unprecedented prospects for attaining the ultimate detection limits of nanoelectromechanical mass spectrometry.

Identifiers

PMID39438454
PMCPMC11496504

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.