Evidence map›Paper›PMID 39438424›Full record

ArticleJournal of natural medicines2025

New sesquiterpenes from the soft coral Litophyton arboreum.

Amany Hamouda Mahmoud, Sabry A H Zidan, Mamdouh Nabil Samy, Abdallah Alian, Mahmoud A A Ibrahim, Mostafa Ahmed Fouad, Mohamed Salah Kamel, Katsuyoshi Matsunami

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of natural medicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The complete mitochondrial genomes ofMitochondrial DNA. Part B, Resources · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amany Hamouda MahmoudDepartment of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.
Sabry A H ZidanDepartment of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut-Branch, Assiut, 71524, Egypt.
Mamdouh Nabil SamyDepartment of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt.
Abdallah AlianDepartment of Zoology, Faculty of Science, Al-Azhar University, Assiut-Branch, Assiut, 71524, Egypt.
Mahmoud A A IbrahimChemistry Department, Faculty of Science, Minia University, Minia, 61519, Egypt.
Mostafa Ahmed FouadDepartment of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt.
Mohamed Salah KamelDepartment of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt. mskamel@yahoo.com.
Katsuyoshi MatsunamiDepartment of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan. matunami@hiroshima-u.ac.jp.ORCID http://orcid.org/0000-0002-8034-0253

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Two new sesquiterpenes; 8α,11-dihydroxy-β-cyperon (2), and 5-epi-7α-hydroxy-( +)-oplopanone (3), were isolated from the soft coral Litophyton arboreum, together with nine known ones, including five sesquiterpenes; 11-hydroxy-8-oxo-β-cyperon (1), alismoxide (4), 5β,8β-epidioxy-11-hydroxy-6-eudesmene (5), chabrolidione B (6), 7-oxo-tri-nor-eudesm-5-en-4β-ol (7), two sterols; 7β-acetoxy-24-methyl-cholesta-5,24(28)-diene-3β,19-diol (8), nebrosteroid M (9), and two glycerol derivatives; chimyl alcohol (10) and batyl alcohol (11). The structures of the isolated compounds were characterized using spectroscopic techniques, predominately HR-ESI-MS, 1D, 2D-NMR, and ECD analyses. Compounds 1-11 were evaluated for their cytotoxic activity against three human cancer-cell lines (A549, MCF-7 and HepG2), and anti-leishmanial potential against the causal parasite, Leishmania major. Compounds 4, 8, and 9 exhibited potent cytotoxic activity against the A549 cell line (IC

Indexed as

AnthozoaAntineoplastic AgentsSesquiterpenesAnimalsCell Line, TumorHumansMolecular StructureAntineoplastic AgentsSesquiterpenesAnti-leishmaniaCytotoxicityLitophyton arboreumNephtheidaeSesquiterpenesSoft corals

Identifiers

PMID39438424
PMCPMC11735488

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.