Evidence map›Paper›PMID 39438295›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025

Prognostic value of serum 25-hydroxyvitamin D levels and malnutrition status on postoperative complications in patients following laryngectomy with neck dissection.

Nemanja Radivojevic, Sandra Sipetic Grujicic, Vesna Suljagic, Stefan Stojkovic, Konstantin Arsovic, Sasa Jakovljevic, Bojana Bukurov, Nenad Arsovic

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. The vitamin DFrontiers in immunology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nemanja RadivojevicFaculty of Medicine, University of Belgrade, Clinic for Otorhinolaryngology and Maxillofacial Surgery, University Clinical Center of Serbia, Pasterova 2, Belgrade, 11000, Serbia. nemanjardv@gmail.com.ORCID http://orcid.org/0000-0001-5117-7904
Sandra Sipetic GrujicicInstitute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.ORCID http://orcid.org/0000-0001-8257-3774
Vesna SuljagicMedical Faculty, Military Medical Academy, Department of Healthcare-Related Infection Control, University of Defense, Military Medical Academy, Belgrade, Serbia.ORCID http://orcid.org/0000-0003-2830-0673
Stefan StojkovicClinic of Gastroenterology and Hepatology, University Clinical Center of Serbia, Belgrade, Serbia.ORCID http://orcid.org/0000-0002-2256-7513
Konstantin ArsovicClinic for Otorhinolaryngology and Maxillofacial Surgery, University Clinical Center of Serbia, Belgrade, Serbia.ORCID http://orcid.org/0009-0002-1200-5469
Sasa JakovljevicFaculty of Medicine, University of Belgrade, Clinic for Otorhinolaryngology and Maxillofacial Surgery, University Clinical Center of Serbia, Pasterova 2, Belgrade, 11000, Serbia.ORCID http://orcid.org/0000-0002-5410-3078
Bojana BukurovFaculty of Medicine, University of Belgrade, Clinic for Otorhinolaryngology and Maxillofacial Surgery, University Clinical Center of Serbia, Pasterova 2, Belgrade, 11000, Serbia.ORCID http://orcid.org/0000-0001-7214-7261
Nenad ArsovicFaculty of Medicine, University of Belgrade, Clinic for Otorhinolaryngology and Maxillofacial Surgery, University Clinical Center of Serbia, Pasterova 2, Belgrade, 11000, Serbia.ORCID http://orcid.org/0000-0001-5277-5746

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative complications (PCs) following total laryngectomy remain a significant challenge, with recent investigations directed toward the impact of nutrition status and vitamin D deficiency.

objectivesTo elucidate the association between preoperative vitamin D level status, malnutrition risk score, and surgical and survival outcomes in patients with advanced laryngeal cancer following total laryngectomy. STUDY

designProspective cohort study.

methodsSixty-four patients with advanced laryngeal carcinoma treated with total laryngectomy were included in the study. Serum levels of 25(OH) D

resultsThe mean serum 25(OH) D level was 37.1 ± 19.4 nmol/L (range 11.0-100.6 nmol/L), with 47% of patients exhibiting vitamin D deficiency and 31% displaying insufficiency. Medium/high MUST score had 53% of patients, and moderate/severe NRI was verified in 48% of patients. Univariate logistic regression analysis identified MUST score, GPS score, neutrophil-to-lymphocyte ratio, and circulating 25(OH) D levels as predictive for the occurrence of PCs. In multivariate analysis, MUST score and circulating 25(OH) D levels remained significantly associated with PCs. Patients with high nutrition risk had significantly lower two-year OS rates compared to the medium and low nutrition risk groups, respectively (30% vs. 62% and 83%, p = 0.010).

conclusionEarly identification of malnourished or patients with vitamin D deficiency and those who would benefit from specific nutritional support could be beneficial for minimizing the risk of development of surgical complications and help improve our clinical outcomes.

Indexed as

Laryngeal NeoplasmsLaryngectomyMalnutritionNeck DissectionPostoperative ComplicationsVitamin DVitamin D DeficiencyAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedNutritional StatusPrognosis25-hydroxyvitamin DVitamin DLaryngeal cancerMalnutritionPostoperative complicationsTotal laryngectomyVitamin D deficiency

Identifiers

PMID39438295

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.