Evidence map›Paper›PMID 39437886›Full record

ArticleJournal of molecular and cellular cardiology2024

Another-regulin regulates cardiomyocyte calcium handling via integration of neuroendocrine signaling with SERCA2a activity.

Keira R Hassel, Aaron M Gibson, Jaroslava Šeflová, Ellen E Cho, N Scott Blair, Catherine D Van Raamsdonk, Douglas M Anderson, Seth L Robia, Catherine A Makarewich

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Keira R HasselThe Heart Institute, Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Molecular and Developmental Biology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Medical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Aaron M GibsonThe Heart Institute, Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Jaroslava ŠeflováDepartment of Cell and Molecular Physiology, Loyola University Chicago, Maywood, IL, USA.
Ellen E ChoDepartment of Cell and Molecular Physiology, Loyola University Chicago, Maywood, IL, USA.
N Scott BlairThe Heart Institute, Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Catherine D Van RaamsdonkDepartment of Medical Genetics, Life Sciences Institute, University of British Columbia, Vancouver, B.C., Canada.
Douglas M AndersonDepartment of Medicine, Cardiovascular Research Institute, University of Rochester Medical Center, Rochester, NY, USA.
Seth L RobiaDepartment of Cell and Molecular Physiology, Loyola University Chicago, Maywood, IL, USA.
Catherine A MakarewichThe Heart Institute, Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA. Electronic address: cat.makarewich@cchmc.org.

Funding

Structural Determinants of Calcium Pump RegulationR01HL092321 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI Seth L Robia · 2008 to 2026
$8.9M
New mechanisms of SERCA regulation: Dimerization and MicropeptidesR01HL143816 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI Seth L Robia, Gianluigi Veglia · 2019 to 2026
$3.6M
Understanding Cardiovascular Disease MechanismsT32HL125204 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Evangelia G Kranias, Jeffery D Molkentin · 2015 to 2026
$3.4M
The NKA Interactome in Health and DiseaseR01HL158649 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI BOSSUYT, JULIE B, ROBIA, SETH L · 2022 to 2025
$2.7M
Microprotein Regulation of Mitochondrial FunctionR01HL160569 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Catherine A Makarewich · 2022 to 2026
$2.0M
Developing DWORF gene therapy to treat heart failure and muscular dystrophyR01HL171221 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Catherine A Makarewich, Jeffery D Molkentin · 2024 to 2026
$1.8M
Determining the regulatory role of microprotein ALN on SERCA2a and heart contractilityF30HL172585 · NHLBI · UNIVERSITY OF CINCINNATI · PI Keira Hassel · 2024 to 2026
$97k
NHLBI NIH HHS F30 HL172585NHLBI NIH HHS R01 HL092321NHLBI NIH HHS R01 HL143816NHLBI NIH HHS R01 HL158649NHLBI NIH HHS R01 HL160569NHLBI NIH HHS R01 HL171221NHLBI NIH HHS T32 HL125204
6 · The paper itself

Abstract

Calcium (Ca

Indexed as

CalciumMice, KnockoutMyocytes, CardiacSarcoplasmic Reticulum Calcium-Transporting ATPasesAnimalsCalcium SignalingMicePhosphorylationProtein BindingProtein Processing, Post-TranslationalSignal TransductionCalciumSarcoplasmic Reticulum Calcium-Transporting ATPasesAnother-regulinCalciumMicroproteinNeuroendocrine signalingSERCA2a

Identifiers

PMID39437886
PMCPMC11588527

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.