Evidence map›Paper›PMID 39437885›Full record

ArticleJournal of molecular and cellular cardiology2024

Inhibition of cardiomyocyte neddylation impairs embryonic cardiac morphogenesis.

Rodney Littlejohn, Josue Zambrano-Carrasco, Jianqiu Zou, Yali Yao, Il-Man Kim, Jiliang Zhou, Jie Li, Huabo Su

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rodney LittlejohnVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, United States.
Josue Zambrano-CarrascoVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, United States.
Jianqiu ZouVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, United States.
Yali YaoVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, United States.
Il-Man KimVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, United States; Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine, Indianapolis, Indiana, United States.
Jiliang ZhouDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA, United States.
Jie LiVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, United States.
Huabo SuVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, United States; Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA, United States. Electronic address: HSU@augusta.edu.

Funding

Neddylation and cardiac protein quality controlR01HL124248 · NHLBI · AUGUSTA UNIVERSITY · PI SU, HUABO · 2014 to 2024
$4.1M
Wrestling stress: role of ufm1 modification in pathological cardiac remodelingR01HL146807 · NHLBI · AUGUSTA UNIVERSITY · PI Jie Li · 2020 to 2026
$2.7M
Mitochondrial quality control in the heartR01HL165205 · NHLBI · AUGUSTA UNIVERSITY · PI SU, HUABO · 2022 to 2025
$2.4M
Elucidating the role of Cullin 3 in the heartR01HL173796 · NHLBI · AUGUSTA UNIVERSITY · PI Huabo Su · 2024 to 2026
$2.0M
Identifying novel pathways targeting endothelial-to-mesenchymal transition during heart failureR01HL146481 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI KIM, IL-MAN · 2019 to 2022
$1.6M
Role of Neddylation in Cardiac DevelopmentF31HL139079 · NHLBI · AUGUSTA UNIVERSITY · PI LITTLEJOHN, RODNEY ERIC · 2017 to 2019
$116k
NHLBI NIH HHS F31 HL139079NHLBI NIH HHS R01 HL124248NHLBI NIH HHS R01 HL146481NHLBI NIH HHS R01 HL146807NHLBI NIH HHS R01 HL165205NHLBI NIH HHS R01 HL173796
6 · The paper itself

Abstract

Heart development is a complex spatiotemporal process involving a series of orchestrated morphogenic events that result in the formation of an efficient pumping organ. How posttranslational mechanisms regulate heart development remains poorly understood. Therefore, we investigate how neddylation, the attachment of NEDD8 to target proteins, coordinates cardiogenesis. Abrogation of neddylation by deleting Nae1 in the heart via Sm22α

Indexed as

Cell ProliferationHeartMorphogenesisMyocytes, CardiacNEDD8 ProteinAnimalsMiceOrganogenesisReceptors, NotchSignal TransductionNEDD8 ProteinNedd8 protein, mouseReceptors, NotchHeart developmentMyocardial hypoplasiaNEDD8NeddylationNotch signalingPosttranslational modification

Identifiers

PMID39437885
PMCPMC11588525

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.