Seeing with an extra sense.

Science foremost derives from our curiosity about the world. Can we make sense of the phenomena we see around us? Given that understanding, can we predict previously unimagined phenomena? How do things work? Can we use what we discover to invent new technologies? One class of questions that has mesmerized observers, dating at least to early cave paintings of hunters and their prey, surrounds the nature of the phenomenon we refer to as life. Over the centuries, scientists have found a broad array of surprisingly different techniques for observing, measuring, characterizing and explaining the living world. Microscopes provide a dazzling view of a previously unseen reality that tells us how living organisms are made up and how their components are organized and move. The tools of molecular science tell us the sequence and structure of the macromolecules that fill cells. The data explosion that has attended the development of a new generation of high-throughput tools for querying the living world demands that we have some way of accounting for those data that both provide intuition and make dangerous predictions with no after-the-fact parametric wiggle room. In this special issue of Current Biology, leading researchers explore how physical approaches have contributed to various fields of biology. Here, to introduce this special issue, I consider some of the ways in which viewing the living through a physical lens allows us to see things that might otherwise remain hidden.