Evidence map›Paper›PMID 39437409›Full record

ArticleASN neuro2024

Astrocytic Ephrin-B1 Regulates Oligodendrocyte Development and Myelination.

Samantha N Sutley-Koury, Alyssa Anderson, Christopher Taitano-Johnson, Moyinoluwa Ajayi, Anna O Kulinich, Kimberly Contreras, Jasmin Regalado, Seema K Tiwari-Woodruff, Iryna M Ethell

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ASN neuro, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Samantha N Sutley-KouryDivision of Biomedical Sciences and Biomedical Sciences Graduate Program, School of Medicine, University of California Riverside, Riverside, California, USA.
Alyssa AndersonDivision of Biomedical Sciences and Biomedical Sciences Graduate Program, School of Medicine, University of California Riverside, Riverside, California, USA.
Christopher Taitano-JohnsonDivision of Biomedical Sciences and Biomedical Sciences Graduate Program, School of Medicine, University of California Riverside, Riverside, California, USA.
Moyinoluwa AjayiDivision of Biomedical Sciences and Biomedical Sciences Graduate Program, School of Medicine, University of California Riverside, Riverside, California, USA.
Anna O KulinichDivision of Biomedical Sciences and Biomedical Sciences Graduate Program, School of Medicine, University of California Riverside, Riverside, California, USA.
Kimberly ContrerasDivision of Biomedical Sciences and Biomedical Sciences Graduate Program, School of Medicine, University of California Riverside, Riverside, California, USA.
Jasmin RegaladoDivision of Biomedical Sciences and Biomedical Sciences Graduate Program, School of Medicine, University of California Riverside, Riverside, California, USA.
Seema K Tiwari-WoodruffDivision of Biomedical Sciences and Biomedical Sciences Graduate Program, School of Medicine, University of California Riverside, Riverside, California, USA.
Iryna M EthellDivision of Biomedical Sciences and Biomedical Sciences Graduate Program, School of Medicine, University of California Riverside, Riverside, California, USA.ORCID 0000-0002-1324-6611

Funding

Demyelination is coupled to neuronal hyperexcitability leading to seizuresR01NS111552 · NINDS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI BINDER, DEVIN K, TIWARI-WOODRUFF, SEEMA K · 2020 to 2024
$1.9M
Molecular and cellular mechanisms of inhibitory synapse developmentR01NS129555 · NINDS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Iryna M Ethell · 2024 to 2026
$1.4M
Elucidating the Role of Astrocytic Ephrin-B1 in Inhibitory Circuit Development in the CA1 HippocampusF31NS129205 · NINDS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI SUTLEY-KOURY, SAMANTHA · 2022 to 2023
$79k
NINDS NIH HHS F31 NS129205NINDS NIH HHS R01 NS111552NINDS NIH HHS R01 NS129555
6 · The paper itself

Abstract

Astrocytes have been implicated in oligodendrocyte development and myelination, however, the mechanisms by which astrocytes regulate oligodendrocytes remain unclear. Our findings suggest a new mechanism that regulates astrocyte-mediated oligodendrocyte development through ephrin-B1 signaling in astrocytes. Using a mouse model, we examined the role of astrocytic ephrin-B1 signaling in oligodendrocyte development by deleting ephrin-B1 specifically in astrocytes during the postnatal days (P)14-P28 period and used mRNA analysis, immunohistochemistry, and mouse behaviors to study its effects on oligodendrocytes and myelination. We found that deletion of astrocytic ephrin-B1 downregulated many genes associated with oligodendrocyte development, myelination, and lipid metabolism in the hippocampus and the corpus callosum. Additionally, we observed a reduced number of oligodendrocytes and impaired myelination in the corpus callosum of astrocyte-specific ephrin-B1 KO mice. Finally, our data show reduced motor strength in these mice exhibiting clasping phenotype and impaired performance in the rotarod test most likely due to impaired myelination. Our studies provide new evidence that astrocytic ephrin-B1 positively regulates oligodendrocyte development and myelination, potentially through astrocyte-oligodendrocyte interactions.

Indexed as

AstrocytesEphrin-B1Myelin SheathOligodendrogliaAnimalsAnimals, NewbornCorpus CallosumHippocampusMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicEfnb1 protein, mouseEphrin-B1Astrocytecorpus callosumdevelopmentephrinhippocampusmyelinoligodendrocyte

Identifiers

PMID39437409
PMCPMC11792131

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.