Evidence map›Paper›PMID 39437336›Full record

ArticleBiochemistry2024

Noncovalent Inhibition and Covalent Inactivation of Proline Dehydrogenase by Analogs of

John J Tanner, Juan Ji, Alexandra N Bogner, Gary K Scott, Sagar M Patel, Javier Seravalli, Kent S Gates, Christopher C Benz, Donald F Becker

Abstract read
In one paragraph

Article in Biochemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Challenges and Prospects for Eradication ofPathogens (Basel, Switzerland) · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

John J TannerDepartment of Biochemistry, University of Missouri, Columbia, Missouri 65211, United States.ORCID 0000-0001-8314-113X
Juan JiDepartment of Biochemistry, University of Missouri, Columbia, Missouri 65211, United States.
Alexandra N BognerDepartment of Biochemistry, University of Missouri, Columbia, Missouri 65211, United States.ORCID 0000-0002-0358-422X
Gary K ScottBuck Institute for Research on Aging, Novato, California 94945, United States.
Sagar M PatelDepartment of Biochemistry and Redox Biology Center, University of Nebraska-Lincoln, Lincoln, Nebraska 68588, United States.ORCID 0000-0002-1700-3350
Javier SeravalliDepartment of Biochemistry and Redox Biology Center, University of Nebraska-Lincoln, Lincoln, Nebraska 68588, United States.
Kent S GatesDepartment of Chemistry, University of Missouri, Columbia, Missouri 65211, United States.ORCID 0000-0002-4218-7411
Christopher C BenzBuck Institute for Research on Aging, Novato, California 94945, United States.
Donald F BeckerDepartment of Biochemistry and Redox Biology Center, University of Nebraska-Lincoln, Lincoln, Nebraska 68588, United States.ORCID 0000-0002-1350-7201

Funding

User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI Nozomi Ando, J Christopher Fromme · 2018 to 2026
$34.2M
Pixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0M
Investigating the Proline Cycle as a Potential Cancer Therapy TargetR01GM132640 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI Donald F Becker, JOHN J TANNER · 2020 to 2026
$1.9M
NIGMS NIH HHS P30 GM124165NIGMS NIH HHS R01 GM132640NIH HHS S10 OD021527
6 · The paper itself

Abstract

The flavoenzyme proline dehydrogenase (PRODH) catalyzes the first step of proline catabolism, the oxidation of l-proline to Δ

Indexed as

GlycineProline OxidaseAlkynesCatalytic DomainCrystallography, X-RayEnzyme InhibitorsHumansKineticsModels, MolecularProlineAlkynesEnzyme InhibitorsGlycineProlineProline Oxidasepropargylglycine

Identifiers

PMID39437336
PMCPMC11602192

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.