Evidence map›Paper›PMID 39437264›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

H3K14ac facilitates the reinstallation of constitutive heterochromatin in

Ruijun Tang, Mengqi Zhou, Yuwei Chen, Zhenghui Jiang, Xunan Fan, Jingheng Zhang, Aiping Dong, Lu Lv, Song Mao, Fang Chen and 4 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. The Many Faces of SetDB1.Epigenomes · 2026
    Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ruijun TangHunan Key Laboratory of Molecular Precision Medicine, Department of Neurosurgery, Xiangya Hospital & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.ORCID 0009-0007-4787-9429
Mengqi ZhouHubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan, Hubei, China.
Yuwei ChenHunan Key Laboratory of Molecular Precision Medicine, Department of Neurosurgery, Xiangya Hospital & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.ORCID 0009-0007-6075-9907
Zhenghui JiangHunan Key Laboratory of Molecular Precision Medicine, Department of Neurosurgery, Xiangya Hospital & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.ORCID 0000-0002-7623-4271
Xunan FanHunan Key Laboratory of Molecular Precision Medicine, Department of Neurosurgery, Xiangya Hospital & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.ORCID 0009-0005-8990-0068
Jingheng ZhangHunan Key Laboratory of Molecular Precision Medicine, Department of Neurosurgery, Xiangya Hospital & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.ORCID 0000-0002-5171-8659
Aiping DongStructural Genomics Consortium, University of Toronto, Toronto, ON, Canada.
Lu LvHunan Key Laboratory of Molecular Precision Medicine, Department of Neurosurgery, Xiangya Hospital & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.ORCID 0009-0007-3824-8334
Song MaoHunan Key Laboratory of Molecular Precision Medicine, Department of Neurosurgery, Xiangya Hospital & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.ORCID 0009-0004-0103-1033
Fang ChenHunan Key Laboratory of Molecular Precision Medicine, Department of Neurosurgery, Xiangya Hospital & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.ORCID 0009-0000-6521-6580
Guanjun GaoSchool of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Jinrong MinHubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan, Hubei, China.ORCID 0000-0001-5210-3130
Ke LiuHubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan, Hubei, China.ORCID 0000-0002-7082-262X
Kai YuanHunan Key Laboratory of Molecular Precision Medicine, Department of Neurosurgery, Xiangya Hospital & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.ORCID 0000-0001-7002-5703

Funding

Department of Science & amp; amp; Technology of Hunan Province 2023RC1028Department of Science & Technology of Hunan Province 2021JJ10054Department of Science & Technology of Hunan Province 2022JJ40762Department of Science & Technology of Hunan Province 2023SK2091MOST | National Key Research and Development Program of China (NKPs) 2021YFC2701200MOST | National Natural Science Foundation of China (NSFC) 31770834MOST | National Natural Science Foundation of China (NSFC) 32101034MOST | National Natural Science Foundation of China (NSFC) 32170821MOST | National Natural Science Foundation of China (NSFC) 32370821MOST | National Natural Science Foundation of China (NSFC) 92153301
6 · The paper itself

Abstract

Constitutive heterochromatin, a fundamental feature of eukaryotic nucleus essential for transposon silencing and genome stability, is rebuilt on various types of repetitive DNA in the zygotic genome during early embryogenesis. However, the molecular program underlying this process remains poorly understood. Here, we show that histone H3 lysine 14 acetylation (H3K14ac) is engaged in the reinstallation of constitutive heterochromatin in

Indexed as

Drosophila melanogasterDrosophila ProteinsHeterochromatinHistone-Lysine N-MethyltransferaseHistonesAcetylationAnimalsDNA Transposable ElementsEmbryo, NonmammalianGene Expression Regulation, DevelopmentalLysineDNA Transposable ElementsDrosophila Proteinsegg protein, DrosophilaHeterochromatinHistone-Lysine N-MethyltransferaseHistonesLysineDrosophilaearly embryoEggless/SetDB1H3K14acheterochromatin

Identifiers

PMID39437264
PMCPMC11331121

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.