Evidence map›Paper›PMID 39436837›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2024

Phenotyping

Constantina A Treaba, Elena Herranz, Valeria T Barletta, Ambica Mehndiratta, Jacob A Sloane, Tobias Granberg, Alessandro Miscioscia, Roberto Bomprezzi, Marco L Loggia, Caterina Mainero

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Multiple sclerosis: 2024 update.Free neuropathology · 2025
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Constantina A TreabaAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.ORCID 0000-0001-8260-207X
Elena HerranzAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.
Valeria T BarlettaAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.
Ambica MehndirattaAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.
Jacob A SloaneDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID 0000-0003-0028-3031
Tobias GranbergDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Alessandro MisciosciaAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.ORCID 0000-0001-7465-6246
Roberto BomprezziDepartment of Neurology, UMass Chan Medical School, Worcester, MA, USA.
Marco L LoggiaAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.
Caterina MaineroAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.

Funding

Cortical mechanisms of disease progression in early multiple sclerosisR01NS078322 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MAINERO, CATERINA · 2013 to 2017
$1.9M
In Vivo Imaging of Cortical Glial Activation Using Advanced Diffusion Magnetic Resonance ImagingR21NS123419 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MAINERO, CATERINA · 2021 to 2021
$480k
NINDS NIH HHS R01 NS078322NINDS NIH HHS R21 NS123419
6 · The paper itself

Abstract

background

objectivesTo investigate the ability of

methodsBased on

resultsLess than half (44%) of non-PRL WM lesions were active on

conclusion

Indexed as

Magnetic Resonance ImagingPositron-Emission TomographyAdultCarbon RadioisotopesFemaleHumansInflammationMaleMiddle AgedMultiple SclerosisPhenotypePyrimidinesReceptors, GABAWhite MatterCarbon Radioisotopes(methyl-(11)C)N-acetyl-N-(2-methoxybenzyl)-2-phenoxy-5-pyridinaminePyrimidinesReceptors, GABATSPO protein, human7T MRIMultiple sclerosispositron emission tomographysmoldering lesionsTSPO

Identifiers

PMID39436837
PMCPMC11742271

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.