Evidence map›Paper›PMID 39436737›Full record

ArticleThe Journal of infectious diseases2025

Neutralizing Antibody Responses to Chlamydia trachomatis in Women and Associations With Chlamydia Outcomes.

Hong Yu, William M Geisler, Chuanbin Dai, Kanupriya Gupta, Gary Cutter, Robert C Brunham

Abstract read
In one paragraph

Article in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. UnveilingiScience · 2025
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hong YuBritish Columbia Centre for Disease Control, University of British Columbia, Vancouver, Canada.
William M GeislerDepartment of Medicine, University of Alabama at Birmingham.ORCID 0000-0002-0603-2404
Chuanbin DaiBritish Columbia Centre for Disease Control, University of British Columbia, Vancouver, Canada.ORCID 0009-0007-8973-0761
Kanupriya GuptaDepartment of Medicine, University of Alabama at Birmingham.
Gary CutterDepartment of Biostatistics, University of Alabama at Birmingham.ORCID 0000-0002-8455-980X
Robert C BrunhamBritish Columbia Centre for Disease Control, University of British Columbia, Vancouver, Canada.

Funding

Mechanisms and Correlates of Immune Protection against Genital Chlamydia in HumansR01AI093692 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GEISLER, WILLIAM M · 2012 to 2023
$4.5M
Host Immune Responses to Chlamydia trachomatis Candidate Vaccine Antigens and their Association with Clinical Correlates of Protective Immunity in WomenR01AI148359 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GEISLER, WILLIAM M · 2020 to 2024
$3.2M
National Institute of Allergy and Infectious DiseasesNIAID NIH HHS R01 AI093692NIAID NIH HHS R01 AI148359NIH HHS R01AI093692
6 · The paper itself

Abstract

We assessed neutralizing antibody responses in a well-characterized cohort of 60 women with different Chlamydia trachomatis infection outcomes noted at a treatment visit and 3-month follow-up. We found varying rates of neutralization (inhibition of C trachomatis) in sera at different dilution levels and varying neutralizing antibody titers across outcomes. Median neutralization rates were significantly higher in sera at high dilutions (1:320-1:1280) from women with spontaneous resolution vs persisting infection before treatment (all P < .05). These findings suggest that neutralizing antibody responses may contribute to protective immunity against chlamydia.

Indexed as

Antibodies, BacterialAntibodies, NeutralizingChlamydia InfectionsChlamydia trachomatisAdolescentAdultFemaleHumansYoung AdultAntibodies, BacterialAntibodies, Neutralizingchlamydia infectionclinical outcomesneutralizing antibodyserologywomen

Identifiers

PMID39436737
PMCPMC11911780

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.