ArticleTranslational vision science & technology2024
Peripheral Contrast Reduction Optically Induced by Scattering Lenses Thickens Peripheral Choroid.
Article in Translational vision science & technology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Purpose: The mechanisms underlying a myopia control strategy using scattering lenses are unclear. Therefore, this study investigates the short-term effects of scatter lenses on central and peripheral choroidal thickness and axial length, which serve as a biomarker in myopia progression research. Methods: In total, 23 participants underwent a 60-minute lens wear phase each to five lens conditions: medium peripheral scattering, high peripheral scattering, medium full-field scattering, high full-field scattering and control (clear lens). Central and peripheral choroidal thickness, foveal axial length, and central visual acuity were measured before and after each lens wear condition. Results: Peripheral choroidal thickening was found after the lens wear phase of the medium peripheral scattering condition (+3.91 ± 5.37 µm, P = 0.04), revealing a significant difference to the control lens condition (P = 0.004), most pronounced in the superior peripheral retina (+1.95 ± 10.74 µm, P = 0.02). In the central retina, significant choroidal thickening was only found in the nasal part after exposure to medium full-field scattering (+3.91 ± 11.72 µm) compared to the control condition (P = 0.001). High peripheral and full-field scattering conditions did not significantly affect central or peripheral choroidal thickness. Visual acuity was significantly reduced in the full-field scattering conditions compared to control and peripheral scattering lenses, with no improvement after 60-minute lens wear. Axial length did not differ significantly after 60-minute exposure to any scattering lens condition or when compared to the control lens. Conclusions: The results indicate a local retinal contrast detection mechanism signals the choroid to thicken peripherally after adaptation to medium peripheral scattering but not high peripheral scattering or full-field scattering at all, while central thickening was only significant nasally after exposure to medium full-field scattering. This emphasizes the importance of the peripheral retina and the level of contrast reduction in the context of myopia research. Translational Relevance: This finding gives insight into the mechanism behind the myopia control strategy inducing peripheral scattering.
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