ArticleProceedings of the National Academy of Sciences of the United States of America2024
Longitudinal hippocampal axis in large-scale cortical systems underlying development and episodic memory.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- The hippocampus becomes topographically and functionally specialized along the longitudinal axis with development.Nature communications · 2026Article
- Thalamo-Lesional Connectivity Signatures of Bilateral Tonic-Clonic Seizures in Focal Cortical Dysplasia-Related Epilepsy.Annals of clinical and translational neurology · 2026Article
- Characterizing functional connectivity gradients for the hippocampus-amygdala complex in healthy and psychiatric cohorts.Brain structure & function · 2026Article
- Hippocampal Long Axis Differentiation in Memory and Seizure Networks.Epilepsy currents · 2026Article
- Lamellar Normative Modelling of the Hippocampus Across the Human Lifespan.bioRxiv : the preprint server for biology · 2026Article
- The In Vivo Microstructural Profile of Human Hippocampal Subfield CA1 and Its Relation to Memory Performance.Human brain mapping · 2026Article
- Different Reliance on Sensory Reinstatement and Internally Transformed Representations during Vivid Retrieval of Visual and Auditory Episodes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- The Development of Hippocampal-Cortical Functional Connectivity in Infants and Toddlers.Human brain mapping · 2026Article
- Hippocampal subregion volumes and preadolescent depression risk in the ABCD sample.Journal of affective disorders · 2025Article
- Local-global functional gradients of the thalamus capturing different aspects of thalamic structure and function.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
10 authors.
Funding
Abstract
The hippocampus is functionally specialized along its longitudinal axis with intricate interactions with cortical systems, which is crucial for understanding development and cognition. Using a well-established connectopic mapping technique on two large resting-state functional MRI datasets, we systematically quantified topographic organization of the hippocampal functional connectivity (hippocampal gradient) and its cortical interaction in developing brains. We revealed hippocampal functional hierarchy within the large-scale cortical brain systems, with the anterior hippocampus preferentially connected to an anterior temporal (AT) pathway and the posterior hippocampus embedded in a posterior medial (PM) pathway. We examined the developmental effects of the primary gradient and its whole-brain functional interaction. We observed increased functional specialization along the hippocampal long axis and found a general whole-brain connectivity shift from the posterior to the anterior hippocampus during development. Using phenotypic predictive modeling, we further delineated how the hippocampus is differentially integrated into the whole-brain cortical hierarchy underlying episodic memory and identified several key nodes within PM/AT systems. Our results highlight the importance of hippocampal gradient and its cortical interaction in development and for supporting episodic memory.
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