Evidence map›Paper›PMID 39436639›Full record

ArticleExperimental physiology2024

Betamethasone improved near-term neonatal lamb lung maturation in experimental maternal asthma.

Joshua L Robinson, Andrea J Roff, Sarah J Hammond, Jack R T Darby, Ashley S Meakin, Stacey L Holman, Andrew Tai, Tim J M Moss, Catherine G Dimasi, Sarah M Jesse and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Joshua L RobinsonRobinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.ORCID https://orcid.org/0000-0001-5267-1496
Andrea J RoffRobinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.ORCID https://orcid.org/0000-0003-2560-7629
Sarah J HammondRobinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.
Jack R T DarbyEarly Origins of Adult Health Research Group, Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.ORCID https://orcid.org/0000-0001-7114-3920
Ashley S MeakinEarly Origins of Adult Health Research Group, Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.
Stacey L HolmanEarly Origins of Adult Health Research Group, Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.
Andrew TaiRobinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.
Tim J M MossDepartment of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia.ORCID https://orcid.org/0000-0002-9408-4027
Catherine G DimasiEarly Origins of Adult Health Research Group, Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.
Sarah M JesseEarly Origins of Adult Health Research Group, Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.
Michael D WieseCentre for Pharmaceutical Innovation, Clinical & Health Sciences, University of South Australia, Adelaide, South Australia, Australia.
Andrew N DaviesBiomedicine Discovery Institute, Monash University, Frankston, Victoria, Australia.
Beverly S MuhlhauslerHealth and Biosecurity, Commonwealth Scientific and Industrial Research Organisation, Adelaide, South Australia, Australia.
Robert J BischofInstitute of Innovation, Science, and Sustainability, Federation University Australia, Berwick, Victoria, Australia.
Megan J WallaceDepartment of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia.
Vicki L CliftonMater Medical Research Institute, University of Queensland, South Brisbane, Queensland, Australia.
Janna L MorrisonEarly Origins of Adult Health Research Group, Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.ORCID https://orcid.org/0000-0002-8602-8519
Michael J StarkRobinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.
Kathryn L GatfordRobinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.ORCID https://orcid.org/0000-0002-2823-3004

Funding

Australian Government Research Training Program ScholarshipsAustralian Government Research Training Program Scholarships and Healthy Development Adelaide/Channel 7 Children's Research Foundation PhD Excellence Supplementary ScholarshipsChannel 7 Children's Research Foundation 20190628National Health and Medical Research Council Senior Research Fellowship APP1136100
6 · The paper itself

Abstract

Maternal asthma is associated with increased rates of neonatal lung disease, and fetuses from asthmatic ewes have fewer surfactant-producing cells and lower surfactant-protein B gene (SFTPB) expression than controls. Antenatal betamethasone increases lung surfactant production in preterm babies, and we therefore tested this therapy in experimental maternal asthma. Ewes were sensitised to house dust mite allergen, and an asthmatic phenotype induced by fortnightly allergen lung challenges; controls received saline. Pregnant asthmatic ewes were randomised to receive antenatal saline (asthma) or 12 mg intramuscular betamethasone (asthma+beta) at 138 and 139 days of gestation (term = 150 days). Lambs were delivered by Caesarean section at 140 days of gestation and ventilated for 45 min before tissue collection. Lung function and structure were similar in control lambs (n = 16, 11 ewes) and lambs from asthma ewes (n = 14, 9 ewes). Dynamic lung compliance was higher in lambs from asthma+beta ewes (n = 12, 8 ewes) compared to those from controls (P = 0.003) or asthma ewes (P = 0.008). Lung expression of surfactant protein genes SFTPA (P = 0.048) and SFTPB (P < 0.001), but not SFTPC (P = 0.177) or SFTPD (P = 0.285), was higher in lambs from asthma+beta than those from asthma ewes. Female lambs had higher tidal volume (P = 0.007), dynamic lung compliance (P < 0.001), and SFTPA (P = 0.037) and SFTPB gene expression (P = 0.030) than males. These data suggest that betamethasone stimulates lung maturation and function of near-term neonates, even in the absence of impairment by maternal asthma.

Indexed as

Animals, NewbornAsthmaBetamethasoneLungAnimalsFemaleMalePregnancyPulmonary Surfactant-Associated Protein BSheepBetamethasonePulmonary Surfactant-Associated Protein Banimaldisease modelsglucocorticoidsnewbornphysiopathologypregnancy complicationsrespiratory distress syndromesheep

Identifiers

PMID39436639
PMCPMC11522833

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.