Evidence map›Paper›PMID 39436616›Full record

ArticlePurinergic signalling2025

Screening herbal and natural product libraries to aid discovery of novel allosteric modulators of human P2X7.

Stefan Bidula, Waraporn Piyasirananda, Hanna Bielecka, Lučka Bibič, Andrew Beekman, Leanne Stokes

Abstract read
In one paragraph

Article in Purinergic signalling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Stefan BidulaSchool of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.
Waraporn PiyasiranandaSchool of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.
Hanna BieleckaSchool of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.
Lučka BibičSchool of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.
Andrew BeekmanSchool of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.
Leanne StokesSchool of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK. l.stokes@uea.ac.uk.

Funding

Biotechnology and Biological Sciences Research Council 1794654Biotechnology and Biological Sciences Research Council BB/N018427/1
6 · The paper itself

Abstract

P2X7 is an emerging therapeutic target for several disorders and diseases due to its role in inflammatory signalling. This study aimed to exploit the unique chemical libraries of plants used in traditional medicinal practices to discover novel allosteric modulators from natural sources. We identified several compounds from the NCI Natural Product library as P2X7 antagonists including confertifolin and digallic acid (IC

Indexed as

Biological ProductsDrug DiscoveryPlant ExtractsPurinergic P2X Receptor AntagonistsReceptors, Purinergic P2X7Allosteric RegulationHEK293 CellsHumansBiological ProductsPlant ExtractsPurinergic P2X Receptor AntagonistsReceptors, Purinergic P2X7Allosteric modulatorConfertifolinDigallic acidDioscinFlavonoidsP2X7ScopafunginTraditional Medicine

Identifiers

PMID39436616
PMCPMC12062478

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.