Evidence map›Paper›PMID 39436555›Full record

ArticleActa neurologica Belgica2025

Safety and efficacy of bridging intravenous thrombolysis plus mechanical thrombectomy versus direct mechanical thrombectomy in different age groups of acute ischemic stroke patients.

Federico Marrama, Alfredo Paolo Mascolo, Fabrizio Sallustio, Mario Bovino, Alessandro Rocco, Federica D'Agostino, Valerio Da Ros, Daniele Morosetti, Francesco Mori, Giordano Lacidogna and 4 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Acta neurologica Belgica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Federico MarramaComprehensive Stroke Center, Department of Systems Medicine, University of Rome Tor Vergata, Rome, 00133, Italy.
Alfredo Paolo MascoloComprehensive Stroke Center, Department of Systems Medicine, University of Rome Tor Vergata, Rome, 00133, Italy. alfredopaolo.mascolo@gmail.com.
Fabrizio SallustioComprehensive Stroke Center, Department of Systems Medicine, University of Rome Tor Vergata, Rome, 00133, Italy.
Mario BovinoComprehensive Stroke Center, Department of Systems Medicine, University of Rome Tor Vergata, Rome, 00133, Italy.
Alessandro RoccoComprehensive Stroke Center, Department of Systems Medicine, University of Rome Tor Vergata, Rome, 00133, Italy.
Federica D'AgostinoComprehensive Stroke Center, Department of Systems Medicine, University of Rome Tor Vergata, Rome, 00133, Italy.
Valerio Da RosInterventional Radiology Unit, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
Daniele MorosettiInterventional Radiology Unit, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
Francesco MoriComprehensive Stroke Center, Department of Systems Medicine, University of Rome Tor Vergata, Rome, 00133, Italy.
Giordano LacidognaComprehensive Stroke Center, Department of Systems Medicine, University of Rome Tor Vergata, Rome, 00133, Italy.
Ilaria MaestriniComprehensive Stroke Center, Department of Systems Medicine, University of Rome Tor Vergata, Rome, 00133, Italy.
Fana AlemsegedDepartment of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, Australia.
Valentina PanettaL'altrastatistica srl - Consultancy & Training- Biostatistics office, Rome, Italy.
Marina DiomediComprehensive Stroke Center, Department of Systems Medicine, University of Rome Tor Vergata, Rome, 00133, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the safety and efficacy of bridging intravenous thrombolysis plus mechanical thrombectomy (MT) versus direct MT in different age groups of patients with acute ischemic stroke (AIS) secondary to large vessel occlusion (LVO) of the anterior circulation.

methodsConsecutive patients from the prospective endovascular stroke registry of the Comprehensive Stroke Center, University of Rome Tor Vergata, Italy, between January 2015 and June 2021 were retrospectively analyzed. Patients were divided into age groups (≤ 80 years old and > 80 years old); for each age group, they were further divided in the bridging therapy group and the direct MT group. We performed a propensity score analysis according to baseline characteristics. Safety outcomes were any intracerebral hemorrhage (ICH), symptomatic ICH (sICH) and 3-month mortality. Efficacy outcomes were successful recanalization (modified Thrombolysis in Cerebral Infarction, mTICI, score ≥ 2b) and 3-month functional independence (modified Rankin Scale, mRS, ≤ 2).

resultsWe included 761 AIS patients with anterior circulation LVO (mean age 73.5 ± 12.8 years; 44.8% males; mean baseline NIHSS 16 ± 5). After propensity score, there were 365 patients ≤ 80 years old (52% bridging therapy) and 187 patients > 80 years old (57% bridging therapy). In both age groups of patients, we found no statistically significant differences in the rates of any ICH, sICH, successful recanalization and 3-month mortality and functional independence between bridging therapy and direct MT groups.

conclusionIn our population, safety and efficacy outcomes of bridging therapy versus direct MT did not differ in both AIS patients ≤ 80 and > 80 years old.

Indexed as

Fibrinolytic AgentsIschemic StrokeThrombectomyThrombolytic TherapyAgedAged, 80 and overAge FactorsCombined Modality TherapyFemaleHumansMaleMiddle AgedRegistriesRetrospective StudiesTreatment OutcomeFibrinolytic AgentsAcute ischemic strokeBridging therapyDirect mechanical thrombectomyOld age

Identifiers

PMID39436555

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.