ArticleeLife2024
DYRK1A interacts with the tuberous sclerosis complex and promotes mTORC1 activity.
Abstract read
In one paragraph
Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- A genome-wide CRISPR screen defines host determinants of earlyInfection and immunity · 2026Article
- Integrative Insights Into DYRK1A From Molecular Function to Therapeutic Advancement.Chemical biology & drug design · 2026Review
- DYRK1A enhances antitumor immunity in type 1 conventional dendritic cells via mTORC1 activation.The Journal of clinical investigation · 2026Article
- A genome-wide CRISPR screen defines host determinants of earlybioRxiv : the preprint server for biology · 2026Article
- Tuberous sclerosis complex.Nature reviews. Disease primers · 2026Review
- Up-regulation of Minibrain/DYRK1A contributes to macrocephaly and brain overgrowth in aProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Jub-induced phosphorylation of Warts inhibits its activity and recruitment into biomolecular condensates.Cell reports · 2025Article
- New insights into tuberous sclerosis complex: from structure to pathogenesis.Frontiers in cell and developmental biology · 2025Review
- Analysis of 1386 epileptogenic brain lesions reveals association with DYRK1A and EGFR.Nature communications · 2024Article
- Article
Corrections and comments
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Authors and funding
18 authors.
Pinhua Wang *State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.
Sunayana Sarkar *Tata Institute of Fundamental Research, Hyderabad, India.
Menghuan Zhang *State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.
Tingting XiaoState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.
Fenhua KongState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.
Zhe ZhangState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.
Deepa BalasubramanianTata Institute of Fundamental Research, Hyderabad, India.
Nandan JayaramCSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.
Sayantan DattaTata Institute of Fundamental Research, Hyderabad, India.
Ruyu HeState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.
Ping WuNational Facility for Protein Science in Shanghai, Zhangjiang Lab, Shanghai, China.
Peng ChaoNational Facility for Protein Science in Shanghai, Zhangjiang Lab, Shanghai, China.
Ying ZhangStowers Institute for Medical Research, Kansas City, United States.
Michael WashburnStowers Institute for Medical Research, Kansas City, United States.ORCID https://orcid.org/0000-0001-7568-2585
Laurence A FlorensStowers Institute for Medical Research, Kansas City, United States.ORCID https://orcid.org/0000-0002-9310-6650
Sonal Nagarkar-JaiswalCSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.ORCID https://orcid.org/0000-0002-2369-3714
Manish JaiswalTata Institute of Fundamental Research, Hyderabad, India.ORCID https://orcid.org/0000-0001-8360-8289
Man MohanState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.ORCID https://orcid.org/0000-0002-8811-8542
Funding
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5MDepartment of Atomic Energy, Government of India RTI 4007Department of Biotechnology, Ministry of Science & Technology, India BT/PR32873/BRB/10/1850/2020Department of Biotechnology, Ministry of Science & Technology, India BT/RLF/Re-entry/06/2016Department of Science and Technology, Ministry of Science and Technology, India CRG/2020/003275National Natural Science Foundation of China 31471206NIH HHS P40 OD018537Wellcome TrustWellcome Trust/DBT India Alliance IA/I/18/1/503629
Abstract
DYRK1A, a ubiquitously expressed kinase
Indexed as
Dyrk KinasesMechanistic Target of Rapamycin Complex 1Protein Serine-Threonine KinasesProtein-Tyrosine KinasesTuberous Sclerosis Complex 2 ProteinAnimalsCell SizeDrosophilaDrosophila ProteinsGene Knockdown TechniquesHEK293 CellsHumansMultiprotein ComplexesPhosphorylationProtein BindingProteomicsDrosophila ProteinsDYRK1A protein, humanDyrk KinasesMechanistic Target of Rapamycin Complex 1mnb protein, DrosophilaMultiprotein ComplexesProtein Serine-Threonine KinasesProtein-Tyrosine KinasesTSC1 protein, humanTSC2 protein, humanTuberous Sclerosis Complex 1 ProteinTuberous Sclerosis Complex 2 ProteinTumor Suppressor Proteinsbiochemistrycell biologycell growthchemical biologyD. melanogasterDrosophila melanogasterDYRK1Amicrocephaly
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.