ArticleImmunity, inflammation and disease2024
Dynamic changes in macrophage polarization during the resolution phase of periodontal disease.
Article in Immunity, inflammation and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Dicer-independent miR-451a is upregulated in periodontitis and potentiates inflammation by impairing macrophage polarization and SOCS activity.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Article
- IL-17 Receptor inhibition with brodalumab limits experimental periodontitis.Journal of translational medicine · 2026Article
- Longitudinal Salivary Immunophenotyping Reveals Distinct Cellular Signatures of Periodontal Disease Activity and Resolution.bioRxiv : the preprint server for biology · 2026Article
- CXCL16 Promotes the Development of Chronic Atrophic Gastritis by Regulating M1 Macrophage Polarisation.Journal of inflammation research · 2026Article
- The macrophage polarization-ferroptosis axis as a therapeutically targetable immunometabolic framework in periodontitis.Frontiers in immunology · 2026Review
- Herpesvirus Simplex Virus-1 Exploits Inflammation to Infect Periodontal Stem Cells and Disrupt Lineage Commitment.Journal of periodontal research · 2025Article
- Enzymatic cottonseed protein alleviates DSS-induced enteritis in juvenile yellow catfish (Pelteobagrus fulvidraco): focus on macrophage polarization and necroptosis in the intestine.Journal of animal science and biotechnology · 2025Article
- IRF3 Promotes Production of IL-6 and Nitric Oxide but Represses CCL22 in RAW264.7 Macrophage Cells Exposed to Lipopolysaccharides in Culture.Journal of inflammation research · 2025Article
- Dynamic changes in macrophage polarization during the resolution phase of periodontal disease.Immunity, inflammation and disease · 2024Article
- PGRN is involved in macrophage M2 polarization regulation through TNFR2 in periodontitis.Journal of translational medicine · 2024Article
- Periodontal Disease, Local and Systemic Inflammation in Puerto Ricans with Type 2 Diabetes Mellitus.Biomedicines · 2023Article
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Authors and funding
7 authors.
Funding
Abstract
aimPolarization of macrophages (Mφ) is a well-controlled axis with considerable consequences in both the pro-inflammatory and resolution phases of inflammation. We aimed to determine if periodontal therapy may instigate M1 to M2 Mφ polarization favoring resolution of inflammation within periodontal tissues.
methodsGingival biopsies were excised from subjects diagnosed with Stage III, Grade B periodontitis before and 4-6 weeks after nonsurgical periodontal therapy. Total RNA was isolated and pro- and anti-inflammatory markers associated with Mφ polarization assessed by RT-qPCR. Mice were subject to ligature-induced periodontitis and gingival tissues collected after 8 days in-situ or 10 days after ligature removal and M1 and M2 Mφ markers examined by RT-qPCR and flow cytometry.
resultsIn human samples, improvement in clinical parameters posttherapy correlates with reduced bacterial burden, downregulation in M1 (TNF-α, STAT1, CXCL10, and miR-155), and elevated levels of M2 (STAT6, TGM2, CCL22, and IL-10) Mφ markers. In a murine model of resolution of LIP, we observed reduced levels of M1 Mφ markers cox2, iNOS2, F4/80+CD80+, and F4/80+CD86+ and elevated levels of M2-like Mφ markers tgm2, arg1, F4/80+CD206+ and F4/80+CD163+ corroborated human findings.
conclusionResolution of periodontal inflammation is associated with M1 to M2 Mφ polarization after nonsurgical periodontal therapy. Assessment of Mφ markers can provide relevant clinical information on the successful response of periodontal therapy and may be used to target nonresponders.
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