Evidence map›Paper›PMID 39436109›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2024

KCNB1-Leptin receptor complexes couple electric and endocrine function in the melanocortin neurons of the hypothalamus.

Elena Forzisi-Kathera-Ibarra, Chanmee Jo, Leonard Castillo, Anika Gaur, Prachi Lad, Alessandro Bortolami, Christian Roser, Srinidi Venkateswaran, Stefania Dutto, Matthew Selby and 3 more

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Ion channels and actin: A tale of two friends.Histology and histopathology · 2025
    Review
  5. KCNB1-Leptin receptor complexes couple electric and endocrine function in the melanocortin neurons of the hypothalamus.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  6. Frontiers in neurology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Elena Forzisi-Kathera-IbarraDepartment of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA.ORCID 0000-0002-3271-7052
Chanmee JoDepartment of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA.
Leonard CastilloDepartment of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA.
Anika GaurDepartment of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA.
Prachi LadDepartment of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA.
Alessandro BortolamiDepartment of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA.ORCID 0000-0001-8016-8820
Christian RoserDepartment of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA.
Srinidi VenkateswaranDepartment of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA.
Stefania DuttoDepartment of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA.
Matthew SelbyDepartment of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey, USA.ORCID 0000-0003-2625-0537
Harini SampathDepartment of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey, USA.ORCID 0000-0001-7339-7115
Ping-Yue PanDepartment of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA.ORCID 0000-0002-2805-6810
Federico SestiDepartment of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA.ORCID 0000-0002-2761-9693

Funding

Oxidation of K+ channels mediates an amyloidogenic pathway common to Alzheimer's disease and TBIR01AG060919 · NIA · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI SESTI, FEDERICO · 2019 to 2023
$2.0M
HHS | National Institutes of Health (NIH) R01AG060919National Science Foundation (NSF) 2030348NIA NIH HHS R01 AG060919
6 · The paper itself

Abstract

The neurons of the melanocortin system regulate feeding and energy homeostasis through a combination of electrical and endocrine mechanisms. However, the molecular basis for this functional heterogeneity is poorly understood. Here, a voltage-gated potassium (Kv

Indexed as

HypothalamusLeptinMice, KnockoutNeuronsPro-OpiomelanocortinReceptors, LeptinShab Potassium ChannelsAnimalsArcuate Nucleus of HypothalamusMaleMelanocortinsMiceMice, Inbred C57BLSignal TransductionSTAT3 Transcription FactorLeptinMelanocortinsPro-OpiomelanocortinReceptors, LeptinShab Potassium ChannelsSTAT3 Transcription FactorhypothalamusK+ channelleptinmelanocortinobesityPOMCpotassium channel

Identifiers

PMID39436109
PMCPMC11556505

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.