Evidence map›Paper›PMID 39436105›Full record

SynthesismSphere2024

Genetic insight into the relationship between inflammatory bowel disease and

Kelly C Cushing-Damm, Yanhua Chen, Xiaomeng Du, Annapurna Kuppa, Chinmay Raut, Antonino Oliveri, Vincent L Chen, Brett Vanderwerff, Matt Zawistowski, Krishna Rao and 2 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in mSphere, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Association betweenmedRxiv : the preprint server for health sciences · 2026
    Article
  2. Article
  3. Article
  4. The host genes influencingFrontiers in cellular and infection microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kelly C Cushing-DammDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0003-3914-9673
Yanhua ChenDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA.
Xiaomeng DuDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA.
Annapurna KuppaDepartment of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, Michigan, USA.
Chinmay RautDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA.
Antonino OliveriDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA.
Vincent L ChenDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA.
Brett VanderwerffDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Matt ZawistowskiDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Krishna RaoDepartment of Internal Medicine, Division of Infectious Diseases, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-9213-7850
Peter HigginsDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA.
Elizabeth K SpeliotesDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA.

Funding

University of Michigan Training Program in Genomic ScienceT32HG000040 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sebastian Zoellner · 1995 to 2026
$16.4M
Training Program in Gastrointestinal EpidemiologyT32DK062708 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Peter D.R. Higgins, Elliot Tapper · 2003 to 2026
$3.9M
Human population based genetic studies to elucidate the biology of NAFLDR01DK107904 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SPELIOTES, ELIZABETH K · 2016 to 2020
$3.4M
Identification and functional impact of NAFLD associated genetic variantsR01DK106621 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SPELIOTES, ELIZABETH K · 2015 to 2019
$3.3M
Measuring Molecular and Mechanical Outcomes of Endoscopic Dilation of Fibrotic StricturesR01DK125687 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Peter D.R. Higgins, Guan Xu · 2020 to 2026
$3.3M
Integrative Polygenic Genetic Studies of Non-alcoholic Fatty Liver DiseaseR01DK131787 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SPELIOTES, ELIZABETH K · 2022 to 2025
$2.7M
Data-Driven Interventions for Reducing C. difficile IncidenceR01HS027431 · AHRQ · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAO, KRISHNA, WIENS, JENNA · 2020 to 2024
$2.4M
Inhibiting Bcl-2-regulated intestinal fibrosis in models of Crohn’s DiseaseR01DK118154 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HIGGINS, PETER D.R. · 2018 to 2022
$2.3M
Predictive models for incident cirrhosis in non-alcoholic fatty liver disease using genetic and electronic medical record-based risk factorsK08DK132312 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Vincent Lingzhi Chen · 2022 to 2026
$834k
Precision Medicine in Inflammatory Bowel Disease: Refining the Clinical and Genomic Predictors of Response to Anti-IL-12/23 TherapyK08DK133640 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kelly Colleen Cushing-Damm · 2023 to 2026
$669k
AHRQ HHS R01 HS027431NHGRI NIH HHS T32 HG000040NIDDK NIH HHS K08 DK132312NIDDK NIH HHS K08 DK133640NIDDK NIH HHS R01 DK106621NIDDK NIH HHS R01 DK107904NIDDK NIH HHS R01 DK118154NIDDK NIH HHS R01 DK125687NIDDK NIH HHS R01 DK131787NIDDK NIH HHS T32 DK062708
6 · The paper itself

Abstract

Patients with inflammatory bowel disease (IBD) are at increased risk of

Indexed as

Clostridium InfectionsGenetic Predisposition to DiseaseInflammatory Bowel DiseasesPolymorphism, Single NucleotideAllelesClostridioides difficileGenome-Wide Association StudyHumansMendelian Randomization AnalysisMichiganUnited KingdomClostridium difficilegeneticsinflammatory bowel disease

Identifiers

PMID39436105
PMCPMC11580397

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.