Evidence map›Paper›PMID 39435988›Full record

ArticlePharmaceutical biology2024

MicroRNAs from Yishen Tongluo formula can repair sperm DNA damage caused by benzo(

Chenming Zhang, Ruimin Ma, Wenbang Liu, Sicheng Ma, Zulong Wang, Zixue Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chenming ZhangThe Second Clinical Medical School, Henan University of Chinese Medicine, Zhengzhou, Henan, China.
Ruimin MaTraditional Chinese Medicine (ZHONG JING) School, Henan University of Chinese Medicine, Zhengzhou, Henan, China.
Wenbang LiuTraditional Chinese Medicine (ZHONG JING) School, Henan University of Chinese Medicine, Zhengzhou, Henan, China.
Sicheng MaTraditional Chinese Medicine (ZHONG JING) School, Henan University of Chinese Medicine, Zhengzhou, Henan, China.
Zulong WangThe First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China.
Zixue SunHenan Province Hospital of Traditional Chinese Medicine, Zhengzhou, Henan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextPlant microRNAs (miRNAs) present in Yishen Tongluo formula (YSTL, a traditional Chinese herbal medicine formula) are considered as potential therapeutic drugs for reducing the sperm DNA fragmentation index (DFI).

objectiveTo study the effectiveness of plant miRNAs in YSTL for repairing mouse sperm DNA damage caused by benzo( METHODS AND MATERIALS: Twenty-four male SPF ICR (CD1) mice were divided into control, BaP and YSTL groups. A BaP-induced (100 mg/kg) sperm DNA damage model was established in the BaP and YSTL groups, and the mice in the YSTL group were treated with YSTL (23.78 g/kg) for 8 weeks. Sperm DFI was determined

resultsCompared with that of the BaP group, the DFI of the YSTL group decreased (9.57% vs. 18.54%, DISCUSSION AND

conclusionsPlant miRNAs such as miR396-x can penetrate the blood-testis barrier through the digestive system to repair sperm DNA.

Indexed as

Benzo(a)pyreneDNA DamageDrugs, Chinese HerbalMice, Inbred ICRMicroRNAsSpermatozoaAnimalsDNA FragmentationDNA RepairMaleMiceBenzo(a)pyreneDrugs, Chinese HerbalMicroRNAscross-kingdomExogenous microRNAmiR396sperm DNA fragmentation index (DFI)traditional Chinese medicine (TCM)

Identifiers

PMID39435988
PMCPMC11497566

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.