Evidence map›Paper›PMID 39435770›Full record

ReviewImmunological reviews2024

Antibodies in breast milk: Pro-bodies designed for healthy newborn development.

Valerie Verhasselt, Julie Tellier, Rita Carsetti, Burcu Tepekule

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Immunological reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Valerie VerhasseltLarsson-Rosenquist Foundation Centre for Immunology and Breastfeeding, School of Medicine and of BioMedical Sciences, University of Western Australia, Perth, Western Australia, Australia.ORCID https://orcid.org/0000-0002-5732-9048
Julie TellierWalter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Rita CarsettiB-cell Lab, Bambino Gesù Children Hospital, Rome, Italy.
Burcu TepekuleDept of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, USA.

Funding

Family Larsson-Rosenquist FoundationSwiss National Science Foundation Postdoc Mobility
6 · The paper itself

Abstract

This manuscript sheds light on the impact of maternal breast milk antibodies on infant health. Milk antibodies prepare and protect the newborn against environmental exposure, guide and regulate the offspring's immune system, and promote transgenerational adaptation of the immune system to its environment. While the transfer of IgG across the placenta ceases at birth, milk antibodies are continuously replenished by the maternal immune system. They reflect the mother's real-time adaptation to the environment to which the infant is exposed. They cover the infant's upper respiratory and digestive mucosa and are perfectly positioned to control responses to environmental antigens and might also reach their circulation. Maternal antibodies in breast milk play a key role in the immune defense of the developing child, with a major impact on infectious disease susceptibility in both HIC and LMIC. They also influence the development of another major health burden in children-allergies. Finally, emerging evidence shows that milk antibodies also actively shape immune development. Much of this is likely to be mediated by their effect on the seeding, composition and function of the microbiota, but not only. Further understanding of the bridge that maternal antibodies provide between the child and its environment should enable the best interventions to promote healthy development.

Indexed as

Immunity, Maternally-AcquiredMilk, HumanAnimalsAntibodiesBreast FeedingChild DevelopmentFemaleHumansInfant, NewbornPregnancyAntibodiesallergybreast milkimmune imprintingimmunoglobulinsinfectionmicrobiotamucosal immunologyneonate

Identifiers

PMID39435770
PMCPMC11659933

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.