Evidence map›Paper›PMID 39435647›Full record

ArticleFEMS yeast research2024

Rapid identification of the predominant azole-resistant genotype in Candida tropicalis.

Kuo-Yun Tseng, Yu-Chieh Liao, Yin-Zhi Chen, Feng-Chi Chen, Feng-Jui Chen, Huey-Kang Sytwu, Li-Yun Hsieh, Chung-Yu Lan, Hsiu-Jung Lo

Abstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in FEMS yeast research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Kuo-Yun TsengTaiwan Mycology Reference Center, Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli 350401, Taiwan, ROC.
Yu-Chieh LiaoInstitute of Population Health Sciences, National Health Research Institutes, Miaoli 350401, Taiwan, ROC.
Yin-Zhi ChenTaiwan Mycology Reference Center, Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli 350401, Taiwan, ROC.
Feng-Chi ChenInstitute of Population Health Sciences, National Health Research Institutes, Miaoli 350401, Taiwan, ROC.
Feng-Jui ChenTaiwan Mycology Reference Center, Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli 350401, Taiwan, ROC.
Huey-Kang SytwuTaiwan Mycology Reference Center, Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli 350401, Taiwan, ROC.
Li-Yun HsiehTaiwan Mycology Reference Center, Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli 350401, Taiwan, ROC.
Chung-Yu LanInstitute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu 300044, Taiwan, ROC.
Hsiu-Jung LoTaiwan Mycology Reference Center, Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli 350401, Taiwan, ROC.ORCID 0000-0001-8864-5214

Funding

Ministry of Health and Welfare MOHW113-CDC-C-114-144301National Health Research Institutes IV-112-PP-02, IV-112-PP-11, IV-113-PP-01National Science and Technology Council 112-2314-B-400-007
6 · The paper itself

Abstract

Candida tropicalis is a leading cause of nonalbicans candidemia in tropical/subtropical areas and a predominant genotype of azole-resistant C. tropicalis clinical isolates belongs to clade 4. The aim of this study was to reveal markers for rapidly identifying the predominant azole-resistant C. tropicalis genotype. We analysed XYR1, one of the six genes used in the multilocus sequence typing analysis, and SNQ2, an ATP-binding cassette transporter in 281 C. tropicalis, including 120 and 161 from Taiwan and global areas, respectively. Intriguingly, the first 4-mer of codon sequences ATRA of CTRG_05978 (96/119 versus 21/162, P < .001, at phi = 0. 679) and the SNQ2 A2977G resulting in amino acid I993V alternation (105/118 versus 12/163, P < .001, at phi = 0.81) was significantly associated with the clade 4 genotype. The sensitivity and specificity of the clade 4 genotype detection with a combination of SNPs of CTRG_05978 and SNQ2 were 0.812 and 0.994, respectively, at phi = 0.838. Furthermore, we successfully established a TaqMan SNP genotyping assay to identify the clade 4 genotype. Our findings suggest that to improve the management of C. tropicalis infections, rapidly identifying azole-resistant C. tropicalis by detecting SNPs of CTRG_05978 and SNQ2 is promising.

Indexed as

Antifungal AgentsAzolesCandida tropicalisDrug Resistance, FungalGenotypeHumansPolymorphism, Single NucleotideSensitivity and SpecificityTaiwanAntifungal AgentsAzolesCandida tropicalisMLSTSNQ2xylose reductaseXYR1

Identifiers

PMID39435647
PMCPMC11500656

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.