SynthesisWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
Outcomes of dermal substitutes in burns and burn scar reconstruction: A systematic review and meta-analysis.
Synthesis in Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Effectiveness of negative-pressure wound therapy in partial-thickness and full-thickness burns: a systematic review.Acta cirurgica brasileira · 2026Pooled it
- Occupational therapy improves functional recovery and reduces delirium in critically ill adults with and without stroke: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Indications for the use of dermal substitutes in patients with acute burns and in reconstructive surgery after burns: A systematic review.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyPooled it
- Outcomes of dermal substitutes in burns and burn scar reconstruction: A systematic review and meta-analysis.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyPooled it
- Dermal Scaffolds in Complex Extremity Wound Reconstruction: Impact of Early Application on Grafting and Flap Requirements-A Systematic Review.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyPooled it
- Defining dermal matrices: Results of a global Delphi panel in surgical reconstruction.JPRAS open · 2026Article
- Biomimetic Dermal Substitutes for Skin Reconstruction: Advances in Scaffold Design, Biological Integration, and Clinical Performance.Journal of functional biomaterials · 2026Review
- RNA Coding and Transcriptional Regulation in Skin Repair: Insights from Single-Cell Profiling and Implications for Organoid-Based Regenerative Strategies.Life (Basel, Switzerland) · 2026Review
- Generation and ex vivo characterization of a full-thickness substitute of the human urethra by tissue engineering.Bioengineering & translational medicine · 2026Article
- Three-dimensional Bovine Collagen-Elastin Matrix in Soft Tissue Reconstruction: No Detectable Bovine DNA After 1 Year.Plastic and reconstructive surgery. Global open · 2026Article
- The Association of Rose Bengal with Macrophage Polarization and Oxidative Stress Response in Full-Thickness Excisional and Grafted Burn Wounds: A Porcine In Vivo Study.Medicina (Kaunas, Lithuania) · 2026Article
- Safety and efficacy of bio-engineered, autologous dermo-epidermal skin grafts in adolescent and adult burn patients: 1-year results of a prospective, randomized, controlled, multicenter phase IIB clinical trial.EClinicalMedicine · 2025Article
- Evidence-Based Management of Burns: A Narrative Review of Evolving Practices.European burn journal · 2025Review
- Facial Burn Healing With a Polylactic Acid Dermal Matrix: A Case Report on Wound Modulation and Graft-Free Epithelialization.Journal of burn care & research : official publication of the American Burn Association · 2025Article
- [Efficacy of artificial dermis in repairing small to medium-sized deep partial-thickness scalds in infants and young children].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2025Observational
- Bioactive Supramolecular Polymers for Skin Regeneration Following Burn Injury.Biomacromolecules · 2025Article
- Reconstruction of Electrical Burn Wounds Using Acellular Dermal Matrix: A Case Report and Literature Review.Cureus · 2025Article
- The Reconstruction of Various Complex Full-Thickness Skin Defects with a Biodegradable Temporising Matrix: A Case Series.European burn journal · 2025Article
- A Collagen-Elastin Regenerative Dermal Matrix May Generate Unfavorable Results in Head and Neck Postburn Scar Reconstruction: A Case Series.Medicina (Kaunas, Lithuania) · 2025Article
- The Successful Treatment of a Patient with Ehlers-Danlos Syndrome (EDS) After an Extensive Burn Injury: A Case Report.Medicina (Kaunas, Lithuania) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Dermal substitutes have been introduced in burn care to improve wound healing outcomes; however, their use remains limited in standard treatments. This systematic review and meta-analysis aimed to evaluate the outcomes of dermal substitutes in patients with burns and patients requiring burn scar reconstruction and subsequently contribute to optimising the integration of dermal substitutes into clinical practice and reducing the knowledge gap. A comprehensive search across various databases included human studies from peer-reviewed journals on dermal substitutes for deep dermal and full-thickness burns, and scar reconstruction across all ages. Data from comparative trials were extracted, focusing on patient and wound characteristics, treatment specifics, and outcomes related to wound healing and scar quality. Meta-analysis was performed on trials reporting similar post-burn measures, with statistical heterogeneity assessed. Outcomes were presented using mean differences or odds ratios with 95% confidence intervals. A total of 31 comparative trials were included. The overall quality of the studies was considered moderate. The meta-analysis indicated delayed re-epithelialization 4-7 days after treatment with a collagen-elastin matrix compared to split-thickness skin graft in acute burns (-7.30%, p = 0.02). Significant improvement in subjective scar quality was observed with acellular dermal matrix compared to split-thickness skin graft in acute burn wounds 6 months post-operative (-1.95, p <0.01). While acknowledging the initially delayed wound healing, incorporating dermal substitutes into the surgical treatment of burn patients holds promise for enhancing scar quality. However, future research must prioritise outcome measure uniformity, address variations in dermal substitute application, and standardise indications for consistent and effective practices.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.