Evidence map›Paper›PMID 39435538›Full record

Trial reportAnnals of surgery2026

Prospective Multicenter Comprehensive Survey on Male Sexual Dysfunction following Laparoscopic, Robotic, and Transanal Approaches for Rectal Cancer (the LANDMARC Study).

Masakatsu Numata, Tomohiro Yamaguchi, Akio Shiomi, Ryo Inada, Manabu Shiozawa, Keisuke Kazama, Masanori Hotchi, Daisuke Yamamoto, Suguru Hasegawa, Masashi Miguchi and 16 more

Abstract readMulticenter StudyClinical Trial, Phase II
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Essential Updates 2024-2026: Advances in Colorectal Cancer Surgery.Annals of gastroenterological surgery · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Experience with hinotoriJournal of the anus, rectum and colon · 2026
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Masakatsu NumataDepartment of Surgery, Gastroenterological Center, Yokohama City University Medical Center, Kanagawa, Japan.ORCID 0000-0003-0414-0046
Tomohiro YamaguchiDepartment of Gastroenterological Surgery, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.
Akio ShiomiDivision of Colon and Rectal Surgery, Shizuoka Cancer Center Hospital, Shizuoka, Japan.
Ryo InadaDepartment of Gastroenterological Surgery, Kochi Health Sciences Center, Kochi, Japan.
Manabu ShiozawaDepartment of Gastroenterological Surgery, Kanagawa Cancer Center, Kanagawa, Japan.
Keisuke KazamaDepartment of Surgery, Yokohama City University, Kanagawa, Japan.
Masanori HotchiDepartment of Surgery, Ehime Prefectural Central Hospital, Ehime, Japan.
Daisuke YamamotoDepartment of Gastroenterological Surgery, Ishikawa Prefectural Hospital, Ishikawa, Japan.
Suguru HasegawaDepartment of Gastroenterological Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
Masashi MiguchiDepartment of Gastroenterological Surgery, Hiroshima Prefectural Hospital, Hiroshima, Japan.
Shinobu OhnumaDepartment of Surgery, Tohoku University Graduate School of Medicine, Miyagi, Japan.
Kay UeharaDepartment of Gastrointestinal Surgery, Nagoya University Graduate School of Medicine, Aichi, Japan.
Koji MunakataDepartment of Surgery, Ikeda City Hospital, Osaka, Japan.
Yusuke KinugasaDepartment of Gastrointestinal Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Hisanaga HorieDepartment of Surgery, Jichi Medical University, Tochigi, Japan.
Shigeki YamaguchiDivision of Colorectal Surgery, Department of Surgery, Tokyo Women's Medical University, Tokyo, Japan.
Teppei TakeshimaDepartment of Urology, Reproduction Center, Yokohama City University Medical Center, Kanagawa, Japan.
Koya HidaDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Tomonori AkagiFaculty of Medicine, Department of Gastroenterological and Pediatric Surgery, Oita University, Oita, Japan.
Hiroyasu KagawaDivision of Colon and Rectal Surgery, Shizuoka Cancer Center Hospital, Shizuoka, Japan.
Shunsuke OyamadaDepartment of Biostatistics, JORTC Data Center, Tokyo, Japan.
Yasushi RinoDepartment of Surgery, Yokohama City University, Kanagawa, Japan.
Yoshiharu SakaiDepartment of Surgery, Japanese Red Cross Osaka Hospital, Osaka, Japan.
Masahiko WatanabeDepartment of Surgery, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.
Takeshi NaitohDepartment of Lower Gastrointestinal Surgery, Kitasato University School of Medicine, Kanagawa, Japan.
LANDMARC Collaborative Study Group of the Japan Society of Laparoscopic Colorectal Surgery

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the incidence of male sexual dysfunction including erectile dysfunction (ErD) and ejaculatory dysfunction (EjD) after minimally invasive rectal cancer surgery.

backgroundMale sexual dysfunction significantly affects after rectal cancer surgery quality of life. Current assessments using the International Index of Erectile Function-5 are unsuitable for patients with reduced postoperative sexual activity because it assume sexual intercourse. This study addresses this gap using the Erection Hardness Score and custom ejaculatory questionnaires.

methodsThis prospective multicenter open-label phase 2 trial enrolled 399 patients who underwent laparoscopic (Lap), robotic (Ro), or transanal (Ta) rectal cancer surgery. Erection Hardness Score and custom ejaculatory questionnaires assessed ErD, EjD, and potency impairment at 3, 6, and 12 months postoperatively. The rates were assessed in the full analysis set and compared between the Lap and Ro groups after propensity score matching.

resultsAt 12 months, the overall incidences of ErD and EjD were 34.7% and 29.8%, respectively. The Ro group showed a significantly lower EjD rate (25.0%) than the Lap group (40.9%), with no significant difference in ErD. Potency impairment was lower in the Ro group at 6 months (32.7% vs 22.3%) and 12 months (29.0% vs 17.8%) postoperatively. The Ta group showed relatively high ErD and EjD at 3 months, with some recovery at 12 months.

conclusionsMinimally invasive rectal cancer surgery commonly results in ErD, EjD, and potency impairment. Ro surgery provides lower EjD rates and less potency impairment. Comprehensive sexual function assessments are essential to inform patients and improve quality of life outcomes.

Indexed as

Erectile DysfunctionLaparoscopyPostoperative ComplicationsRectal NeoplasmsRobotic Surgical ProceduresSexual Dysfunction, PhysiologicalTransanal Endoscopic SurgeryAdultAgedEjaculationHumansIncidenceMaleMiddle AgedProspective StudiesQuality of Lifeejaculatory dysfunctionerectile dysfunctionlaparoscopic surgeryminimally invasive surgeryrectal cancerrobotic surgerysexual dysfunction

Identifiers

PMID39435538
PMCPMC13056404

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.