ArticleAmerican journal of ophthalmology case reports2024
Crohn's disease-associated keratopathy: A case report.
Article in American journal of ophthalmology case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Corneal Adverse Events Temporally Associated with Anti-TNF-α Therapy: Severe Fibrovascular Pannus and a Non-Pannus Epitheliopathy in Two Cases.International medical case reports journal · 2025Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This study reports a case of Crohn's disease-associated keratopathy that progressed with disease activity. Observations: A 29-year-old man diagnosed with Crohn's disease and receiving systemic adalimumab therapy, presented with an irregular epithelial surface, superior corneal opacity, subepithelial infiltration, pannus with new vessel ingrowth, and punctate epithelial erosions in both corneas. Changes in ophthalmological findings were checked during regular outpatient follow-ups. We also compared the stool calprotectin values obtained at a gastrointestinal clinic during the course of keratopathy. By analyzing the trend of fecal calprotectin levels in this patient, we found that keratopathy worsened as fecal calprotectin levels increased. Corneal neovascularization and infiltration improved as the fecal calprotectin levels decreased. Conclusions and importance: The mechanism of Crohn's disease-associated keratopathy has not been identified but appears to be related to the autoimmune mechanism of Crohn's disease. Managing Crohn's activity by referring to the gastroenterology department should be considered to relieve Crohn's disease-associated keratopathy.
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