Evidence map›Paper›PMID 39434867›Full record

ArticlePNAS nexus2024

The fully activated open state of KCNQ1 controls the cardiac "fight-or-flight" response.

Panpan Hou, Lu Zhao, Ling Zhong, Jingyi Shi, Hong Zhan Wang, Junyuan Gao, Huilin Liu, Joan Zuckerman, Ira S Cohen, Jianmin Cui

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PNAS nexus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Targeting the ICirculation research · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Panpan HouDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Washington University, St. Louis, MO 63130, USA.ORCID https://orcid.org/0000-0001-7694-2262
Lu ZhaoDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Washington University, St. Louis, MO 63130, USA.ORCID https://orcid.org/0000-0003-3533-7693
Ling ZhongDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Washington University, St. Louis, MO 63130, USA.
Jingyi ShiDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Washington University, St. Louis, MO 63130, USA.
Hong Zhan WangDepartment of Physiology and Biophysics, Institute for Molecular Cardiology, Stony Brook University, Stony Brook, NY 11794, USA.
Junyuan GaoDepartment of Physiology and Biophysics, Institute for Molecular Cardiology, Stony Brook University, Stony Brook, NY 11794, USA.ORCID https://orcid.org/0009-0005-8548-7712
Huilin LiuDepartment of Physiology and Biophysics, Institute for Molecular Cardiology, Stony Brook University, Stony Brook, NY 11794, USA.
Joan ZuckermanDepartment of Physiology and Biophysics, Institute for Molecular Cardiology, Stony Brook University, Stony Brook, NY 11794, USA.ORCID https://orcid.org/0009-0000-3561-0069
Ira S CohenDepartment of Physiology and Biophysics, Institute for Molecular Cardiology, Stony Brook University, Stony Brook, NY 11794, USA.ORCID https://orcid.org/0000-0003-2317-5420
Jianmin CuiDepartment of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Washington University, St. Louis, MO 63130, USA.ORCID https://orcid.org/0000-0002-9198-6332

Funding

MANIPULATING IKS AS A THERAPEUTIC APPROACH TO CARDIAC ARRHYTHMIASR01HL126774 · NHLBI · WASHINGTON UNIVERSITY · PI CUI, JIANMIN · 2015 to 2018
$3.1M
A full spectrum rational approach to identify antiarrhythmic agents targeting IKs ChannelsR01HL166628 · NHLBI · STATE UNIVERSITY NEW YORK STONY BROOK · PI Jianmin Cui, RICHARD Z LIN · 2023 to 2026
$2.8M
Gating Mechanisms of KCNQ1/IKS ChannelsR01HL155398 · NHLBI · WASHINGTON UNIVERSITY · PI CUI, JIANMIN · 2021 to 2024
$2.5M
NHLBI NIH HHS R01 HL126774NHLBI NIH HHS R01 HL155398NHLBI NIH HHS R01 HL166628
6 · The paper itself

Abstract

The cardiac KCNQ1 + KCNE1 (I

Indexed as

antiarrhythmia“fight-or-fight” responseIKs channellong QT syndromephosphorylation

Identifiers

PMID39434867
PMCPMC11492796

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.