Evidence map›Paper›PMID 39434865›Full record

ReviewToxicology reports2024

Understanding

Rishvini Kailashnath Pillai, Roshvin Kailashnath Pillai, Vinibha Rajakumari Illankovan, Vinoth Kumarasamy, Satyanarayana Reddy, K Gowtham, Muralikrishnan Dhanasekaran, Vetriselvan Subramaniyan

Abstract readReview
In one paragraph

Review in Toxicology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rishvini Kailashnath PillaiFaculty of Medicine, MAHSA University Jalan SP 2, Bandar Saujana Putra, Jenjarom, Selangor 42610, Malaysia.
Roshvin Kailashnath PillaiFaculty of Medicine, MAHSA University Jalan SP 2, Bandar Saujana Putra, Jenjarom, Selangor 42610, Malaysia.
Vinibha Rajakumari IllankovanCentre for Pre-University Studies, MAHSA University Jalan SP 2, Bandar Saujana Putra, Jenjarom, Selangor 42610, Malaysia.
Vinoth KumarasamyDepartment of Parasitology, Medical Entomology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, 56000 Cheras, Kuala Lumpur, Malaysia.
Satyanarayana ReddyDepartment of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ootacamund 643 001, India.
K GowthamDepartment of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ootacamund 643 001, India.
Muralikrishnan DhanasekaranDepartment of Drug Discovery & Development, Harrison College of Pharmacy, Auburn University, 3306B Walker building, Auburn, AL 36849, United States.
Vetriselvan SubramaniyanDepartment of Medical Sciences, School of Medical and Life Sciences, Sunway University, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Globally, Strongyloides stercoralis is a prevalent nematode parasite infecting over 600 million individuals, predominantly in tropical regions. Despite its widespread occurrence, it is frequently underdiagnosed and neglected, posing significant health risks, particularly to immunocompromised individuals. This parasite's life cycle includes a concerning capability for autoinfection, potentially leading to hyperinfection syndrome with high mortality rates. Alcoholism is recognized as a major risk factor for exacerbating S. stercoralis infections due to its harmful impact on the immune system. Chronic alcohol consumption impairs adaptive immunity by reducing T-cell and B-cell function, which facilitates parasitic infections. This review examines the complex relationship between alcohol abuse and strongyloidiasis, emphasizing the molecular mechanisms involved. Diagnostic challenges and treatment options, particularly the efficacy of antiparasitic drugs like ivermectin, are also discussed. Understanding these interactions is essential for developing improved diagnostic and therapeutic strategies to combat strongyloidiasis, especially among vulnerable populations, highlighting areas for future study.

Indexed as

Alcoholism and immunityAntiparasitic treatmentHyperinfection syndromeStrongyloides stercoralis

Identifiers

PMID39434865
PMCPMC11493194

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.