Evidence map›Paper›PMID 39434850›Full record

ArticleMolecular therapy. Nucleic acids2024

Optimization of a lentivirus-mediated gene therapy targeting HIV-1 RNA to eliminate HIV-1-infected cells.

Amanda B Buckingham, Sophia Ho, Finlay Knops-Mckim, Carin K Ingemarsdotter, Andrew M L Lever

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Amanda B BuckinghamUniversity of Cambridge, Department of Medicine, Level 5 Addenbrooke's Hospital, Hills Rd, Cambridge CB2 0QQ, UK.
Sophia HoUniversity of Cambridge, Department of Medicine, Level 5 Addenbrooke's Hospital, Hills Rd, Cambridge CB2 0QQ, UK.
Finlay Knops-MckimIndependent Researcher, Cambridge, UK.
Carin K IngemarsdotterUniversity of Cambridge, Department of Medicine, Level 5 Addenbrooke's Hospital, Hills Rd, Cambridge CB2 0QQ, UK.
Andrew M L LeverUniversity of Cambridge, Department of Medicine, Level 5 Addenbrooke's Hospital, Hills Rd, Cambridge CB2 0QQ, UK.

Funding

Medical Research Council MC_PC_13059
6 · The paper itself

Abstract

Persistence of HIV-1 in cellular reservoirs results in lifelong infection, with cure achieved only in rare cases through ablation of marrow-derived cells. We report on optimization of an approach that could potentially be aimed at eliminating these reservoirs, hijacking the HIV-1 alternative splicing process to functionalize the herpes simplex virus thymidine kinase (HSVtk)/ganciclovir (GCV) cell suicide system through targeted RNA

Indexed as

gene therapyherpes simplex virusHIV-1HSVtk/GCVlatency reversing agentslatent reservoirlentiviral vectorMT: Oligonucleotides: Therapies and ApplicationsRNA trans-splicingshock and kill

Identifiers

PMID39434850
PMCPMC11491724

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.