Evidence map›Paper›PMID 39434668›Full record

ArticleMolecular and cellular biology2024

Reconstitution of Rab11-FIP4 Expression Rescues Cellular Homeostasis in Cystinosis.

Farhana Rahman, Jennifer L Johnson, Mouad Ait Kbaich, Elsa Meneses-Salas, Aparna Shukla, Danni Chen, William B Kiosses, Evripidis Gavathiotis, Ana Maria Cuervo, Stephanie Cherqui and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Farhana RahmanDepartment of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, California, USA.
Jennifer L JohnsonDepartment of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, California, USA.
Mouad Ait KbaichDepartment of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, California, USA.
Elsa Meneses-SalasDepartment of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, California, USA.
Aparna ShuklaDepartment of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, California, USA.
Danni ChenDepartment of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, California, USA.
William B KiossesDivision of Inflammation Biology, La Jolla Institute for Immunology, La Jolla, California, USA.
Evripidis GavathiotisDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA.
Ana Maria CuervoDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA.
Stephanie CherquiDepartment of Pediatrics, University of California San Diego, La Jolla, California, USA.
Sergio D CatzDepartment of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, California, USA.ORCID 0000-0002-1873-0277

Funding

Neutrophil Survival and Demise During Inflammatory StatesP01HL152958 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI CATZ, SERGIO DANIEL · 2021 to 2025
$12.4M
Vesicular trafficking mechanisms regulating granulocyte functionR01HL088256 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI Sergio Daniel Catz · 2009 to 2026
$9.0M
Molecular and Cellular Mechanisms of the Lysosomal Storage Disease CystinosisR01DK110162 · NIDDK · SCRIPPS RESEARCH INSTITUTE, THE · PI CATZ, SERGIO DANIEL, CHERQUI, STEPHANIE · 2017 to 2025
$4.7M
Lentiviral-transduced hematopoictic stem cell transplantation for cystinosisR01DK090058 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHERQUI, STEPHANIE · 2011 to 2019
$2.7M
Hematopoietic Stem Cell Gene Therapy for Friedreich's ataxiaR01NS108965 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHERQUI, STEPHANIE · 2018 to 2022
$1.7M
Small Molecule inhibitors of late endosomal pro-inflammatory signalingR01AR070837 · NIAMS · SCRIPPS RESEARCH INSTITUTE, THE · PI CATZ, SERGIO DANIEL, ROSEN, HUGH · 2017 to 2019
$1.3M
Automated Multiscale Super-resolution Confocal MicroscopeS10OD030417 · OD · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI KIOSSES, BILL WILLIAM · 2022 to 2022
$514k
NHLBI NIH HHS P01 HL152958NHLBI NIH HHS R01 HL088256NIAMS NIH HHS R01 AR070837NIDDK NIH HHS R01 DK090058NIDDK NIH HHS R01 DK110162NIH HHS S10 OD030417NINDS NIH HHS R01 NS108965
6 · The paper itself

Abstract

Rab11 family interacting protein 4 (Rab11-FIP4) regulates endocytic trafficking. A possible role for Rab11-FIP4 in the regulation of lysosomal function has been proposed, but its precise function in the regulation of cellular homeostasis is unknown. By mRNA array and protein analysis, we found that Rab11-FIP4 is downregulated in the lysosomal storage disease cystinosis, which is caused by genetic defects in the lysosomal cystine transporter, cystinosin. Rescue of Rab11-FIP4 expression in

Indexed as

Amino Acid Transport Systems, NeutralAutophagyCystinosisHomeostasisLysosomesAnimalsAutophagosomesEndoplasmic Reticulum StressFibroblastsHumansLysosomal-Associated Membrane Protein 2Membrane ProteinsMicerab GTP-Binding ProteinsAmino Acid Transport Systems, NeutralCTNS protein, humanLAMP2 protein, humanLysosomal-Associated Membrane Protein 2Membrane Proteinsrab GTP-Binding ProteinsArf6ATF4autophagychaperone-mediated autophagyER stressLysosomal diseaseRab11Rab11-FIP4Rab GTPasestrafficking

Identifiers

PMID39434668
PMCPMC11583627

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.